BACKGROUND: Pancreatic cancer is a highly aggressive malignancy of the digestive system, characterized by insidious onset and rapid progression. Most cases are diagnosed at advanced stages, complicating surgical resection and presenting significant challenges for clinical treatment. Recent advancements have emphasized individualized treatment strategies tailored to patients' specific conditions. Consequently, accurate preoperative assessment is crucial, highlighting the urgent need to develop more reliable predictive models to guide personalized treatment plans. METHODS: A systematic literature search was conducted using Web of Science Core Collection (WoSCC) database, covering publications from January 1, 1995, to October 25, 2024. A comprehensive bibliometric analysis was performed employing analytical tools such as VOSviewer, CiteSpace and Microsoft Excel. RESULTS: This study includes 919 publications authored by 6716 researchers from 3727 institutions in 222 countries and regions. The articles were published in 301 journals, with 1,640 distinct keywords and 25,910 references. China led in publication volume, while the United States garnered the most citations. The top three research institutions in this field were Fudan University, Shanghai Jiao Tong University, and Sun Yat-sen University. Yu Xianjun from Fudan University emerged as the most prolific author with the highest citation count. had the highest publication volume, while the received the most citations. Medical imaging, biochemistry, immunology, bioinformatics, genetics, and interdisciplinary integrative research are the main research disciplines in the field of prognosis prediction for pancreatic cancer. The results of keyword co-occurrence and literature co-citation analysis revealed emerging hotspots and trends in this field, including CA19-9, CT, inflammation, machine learning, tumor microenvironment, radiomics, genes, nomograms, randomized controlled trials, long-term survival, and metastasis. CONCLUSION: This bibliometric analysis provides an overview of research conducted over the past three decades, offering insights into the current state of knowledge and outlining directions for future studies on prognosis prediction models for pancreatic cancer. Biochemical indicators have consistently emerged as key research focal points. The tumor microenvironment represents a currently popular research direction, while bioinformatics, medical imaging, and artificial intelligence are gaining traction as future trends in this field. In the future, prognostic models for pancreatic cancer require further refinement to ensure reliable guidance for therapeutic decision-making.