Bril A, Rochette L
Laboratory of Pharmacodynamics, Faculty of Pharmacy, Dijon, France.
Pharmacology. 1988;36(1):16-26. doi: 10.1159/000138342.
The effects of the intravenously administered antidepressant drugs mianserin, imipramine, metapramine, nomifensine and amineptine against ischaemia and reperfusion arrhythmias were investigated in anaesthetized rats. Imipramine, metapramine, mianserin and high doses of nomifensine (0.5 mg.kg-1) reduced the mortality and the duration of ventricular fibrillation observed following coronary artery ligation. Amineptine was ineffective in preventing early postligation arrhythmias. With the tricyclic antidepressant drugs imipramine and metapramine, the arrhythmias were practically suppressed after 15 min following coronary artery ligation. The incidence of reperfusion arrhythmias was significantly reduced by tricyclic antidepressant drugs. In contrast, amineptine was not effective and did not alter cardiac function. It was suggested that nonspecific effects of these drugs account for their antiarrhythmic action. The most plausible explanation for their antiarrhythmic action may be a quinidine-like cardiac depressant activity.
在麻醉大鼠中研究了静脉注射抗抑郁药物米安色林、丙咪嗪、三甲丙咪嗪、诺米芬辛和阿密替林对缺血及再灌注心律失常的影响。丙咪嗪、三甲丙咪嗪、米安色林及高剂量诺米芬辛（0.5mg·kg-1）可降低冠状动脉结扎后观察到的死亡率及室颤持续时间。阿密替林在预防结扎后早期心律失常方面无效。使用三环类抗抑郁药物丙咪嗪和三甲丙咪嗪时，冠状动脉结扎15分钟后心律失常几乎被抑制。三环类抗抑郁药物可显著降低再灌注心律失常的发生率。相比之下，阿密替林无效且未改变心脏功能。提示这些药物的非特异性作用是其抗心律失常作用的原因。对其抗心律失常作用最合理的解释可能是类似奎尼丁的心脏抑制活性。
