结扎后给予ORG 6001和丙吡胺对麻醉大鼠早期缺血性心律失常的影响。
The effects of postligation administration of ORG 6001 and disopyramide on early ischaemia-induced arrhythmias in the anaesthetized rat.
作者信息
Marshall R J, Muir A W, Winslow E
出版信息
Br J Pharmacol. 1982 Aug;76(4):501-3. doi: 10.1111/j.1476-5381.1982.tb09245.x.
Abstract
The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation-induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).
摘要
静脉注射剂量的Org 6001和丙吡胺（10毫克/千克）在预防性给药时已知可保护麻醉大鼠免受结扎后早期诱导的心律失常影响，在结扎后给药后对其效果进行了评估。在结扎后1分钟给药时，两种药物均大大降低了心室颤动/扑动的发生率，并完全防止了电击死亡（对照组为45%）。在心律失常预期发作前（结扎后4.5分钟）给药时也观察到了保护作用。
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