Jin F L, Zhang L X, Chen K, Tian Y G, Li J S
Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, China; The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450046, China.
Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2020 Dec 20;38(12):948-952. doi: 10.3760/cma.j.cn121094-20200219-00064.
Pneumoconiosis is an occupational lung disease that is mainly caused by diffuse fibrosis of lung tissue due to long-term inhalation of productive dust during occupational activities and retention in the lungs. Macrophages, epithelial cells and other cells can release a large number of cytokines, such as transforming growth factor-β, monocyte chemotactic protein-1, etc. These cytokines can participate in pathologies such as local injury, inflammatory response, and pulmonary fibrosis. This article reviews the role of cytokines in the pathogenesis of pneumoconiosis in order to provide a basis for further research.
尘肺病是一种职业性肺部疾病,主要是由于在职业活动中长期吸入生产性粉尘并滞留在肺部,导致肺组织弥漫性纤维化。巨噬细胞、上皮细胞等细胞可释放大量细胞因子,如转化生长因子-β、单核细胞趋化蛋白-1等。这些细胞因子可参与局部损伤、炎症反应和肺纤维化等病理过程。本文综述细胞因子在尘肺病发病机制中的作用,为进一步研究提供依据。