Rzepka-Migut Beata, Paprocka Justyna
Department of Pediatric Neurology and Pediatrics, St. Queen Jadwiga's Regional Clinical Hospital No. 2, 35-301 Rzeszów, Poland.
Department of Pediatric Neurology, Faculty of Medical Science in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Life (Basel). 2021 Jan 4;11(1):26. doi: 10.3390/life11010026.
Epilepsy is one of the most common neurological diseases in children. There is an unmet need for new objective methods that would facilitate and accelerate the diagnostic process, thus improving the prognosis. In many studies, the participation of microRNA in epileptogenesis has been confirmed. Therefore, it seems to be a promising candidate for this role. Scientists show the possibility of using microRNAs as diagnostic and predictive biomarkers as well as novel therapeutic targets. Children with epilepsy would benefit particularly from the use of this innovative method. However, the number of studies related to this age group is very limited. This review is based on 10 studies in children and summarizes the information collected from studies on animal models and the adult population. A total of 136 manuscripts were included in the analysis. The aim of the review was to facilitate the design of studies in children and to draw attention to the challenges and traps related to the analysis of the results. Our review suggests a high potential for the use of microRNAs and the need for further research.
癫痫是儿童最常见的神经系统疾病之一。对于能够促进和加速诊断过程从而改善预后的新的客观方法存在未满足的需求。在许多研究中，已证实微小RNA参与癫痫的发生。因此，它似乎是担任这一角色的有前途的候选者。科学家们展示了将微小RNA用作诊断和预测生物标志物以及新型治疗靶点的可能性。癫痫患儿将特别受益于这种创新方法的使用。然而，与该年龄组相关的研究数量非常有限。本综述基于对儿童的10项研究，并总结了从动物模型和成人人群研究中收集的信息。分析共纳入136篇手稿。该综述的目的是促进儿童研究的设计，并提请注意与结果分析相关的挑战和陷阱。我们的综述表明微小RNA具有很高的应用潜力，并且需要进一步研究。
