Behzadi Payam, Baráth Zoltán, Gajdács Márió
Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran 37541-374, Iran.
Department of Prosthodontics, Faculty of Dentistry, University of Szeged, Tisza Lajos körút 62-64, 6720 Szeged, Hungary.
Antibiotics (Basel). 2021 Jan 4;10(1):42. doi: 10.3390/antibiotics10010042.
is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens present a concerning therapeutic challenge to clinicians, both in community and in hospital settings, due to their increasing prevalence of resistance, and this may lead to prolonged therapy, sequelae, and excess mortality in the affected patient population. The resistance mechanisms of may be classified into intrinsic and acquired resistance mechanisms. These mechanisms lead to occurrence of resistant strains against important antibiotics-relevant in the treatment of infections-such as β-lactams, quinolones, aminoglycosides, and colistin. The occurrence of a specific resistotype of , namely the emergence of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S) strains, has received substantial attention from clinical microbiologists and infection control specialists; nevertheless, the available literature on this topic is still scarce. The aim of this present review paper is to provide a concise summary on the adaptability, virulence, and antibiotic resistance of to a readership of basic scientists and clinicians.
是非发酵革兰氏阴性菌中最常见的感染原因，主要影响免疫功能低下的患者，但在免疫功能正常的患者中其致病作用也不应被忽视。由于这些病原体的耐药性日益普遍，无论是在社区还是医院环境中，它们都给临床医生带来了严峻的治疗挑战，这可能导致受影响患者群体的治疗时间延长、出现后遗症以及死亡率过高。的耐药机制可分为固有耐药机制和获得性耐药机制。这些机制导致出现对治疗感染重要的抗生素（如β-内酰胺类、喹诺酮类、氨基糖苷类和黏菌素）耐药的菌株。一种特定的耐药类型，即碳青霉烯耐药但头孢菌素敏感（Car-R/Ceph-S）菌株的出现，已受到临床微生物学家和感染控制专家的广泛关注；然而，关于这一主题的现有文献仍然很少。本综述文章的目的是向基础科学家和临床医生读者简要总结的适应性、毒力和抗生素耐药性。
