Hemati S, Kouhsari E, Sadeghifard N, Maleki A, Omidi N, Mahdavi Z, Pakzad I
Clinical Microbiology Research Centre, Ilam University of Medical Sciences, Ilam, Iran.
Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
New Microbes New Infect. 2020 Oct 19;38:100794. doi: 10.1016/j.nmni.2020.100794. eCollection 2020 Nov.
It is clear that biofilm formation causes many serious health-care problems. Interestingly, sub minimum inhibitory concentrations (sub-MICs) of some biocides can induce biofilm formation in bacteria. We investigated whether sub-MICs of Savlon, chlorhexidine and deconex®, as biocidal products, can induce biofilm formation in clinical isolates of . To determine MICs and biofilm formation, we performed microtitre plate assays. All three biocides induced biofilm formation at sub-MICs; Savlon was the most successful antiseptic agent to induce biofilm formation among isolates. Deconex had the best inhibition effect on planktonic cultures of isolates. We concluded that sub-MICs of Savlon and deconex could significantly induce biofilm formation.
显然，生物膜形成会引发许多严重的医疗保健问题。有趣的是，某些杀菌剂的亚最小抑菌浓度（sub-MICs）可诱导细菌形成生物膜。我们研究了作为杀菌产品的Savlon、洗必泰和百毒杀®的亚最小抑菌浓度是否能在[具体细菌名称]的临床分离株中诱导生物膜形成。为了确定最小抑菌浓度和生物膜形成情况，我们进行了微量滴定板试验。所有三种杀菌剂在亚最小抑菌浓度时均能诱导生物膜形成；在[具体细菌名称]分离株中，Savlon是诱导生物膜形成最有效的防腐剂。百毒杀对[具体细菌名称]分离株的浮游培养物具有最佳抑制效果。我们得出结论，Savlon和百毒杀的亚最小抑菌浓度可显著诱导生物膜形成。
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