Johnson P E, Kernahan D A, Bauer B S
Division of Plastic Surgery, Children's Memorial Hospital, Chicago, Ill.
Plast Reconstr Surg. 1988 Mar;81(3):390-7. doi: 10.1097/00006534-198803000-00013.
To evaluate the dermal and epidermal response to soft-tissue expansion in the pig, round tissue expanders were placed dorsally under tattooed patterns and inflated over 6 weeks. Surface area, skin thickness, histologic changes, and collagen content were evaluated at 6-week intervals. Epidermal thickening and dermal thinning were observed. Dermal thinning persisted 36 weeks after expansion. Dermal collagen content was decreased, although collagen density remained unchanged. Total collagen content calculated within an expanded square grid increased. These data support a theoretical gain in the dermal layer as well as epidermal layer in response to tissue expansion.
为评估猪对软组织扩张的真皮和表皮反应，将圆形组织扩张器置于背部纹身图案下方，并在6周内进行充气。每隔6周评估表面积、皮肤厚度、组织学变化和胶原蛋白含量。观察到表皮增厚和真皮变薄。扩张后36周真皮变薄仍持续存在。真皮胶原蛋白含量降低，尽管胶原蛋白密度保持不变。在扩张的方形网格内计算的总胶原蛋白含量增加。这些数据支持了在组织扩张反应中真皮层和表皮层理论上的增加。
