M1 巨噬细胞参与病因不明的胎盘慢性绒毛膜炎的发病机制。
M1 macrophages involved in the pathogenesis of placental chronic villitis of unknown etiology.
机构信息
Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil.
出版信息
J Matern Fetal Neonatal Med. 2022 Dec;35(25):4847-4852. doi: 10.1080/14767058.2020.1869930. Epub 2021 Jan 6.
INTRODUCTION
Placental villitis is characterized by the presence of inflammatory infiltrate in the placental villous. The objective of this study was to characterize in villitis of unknown etiology (VUE) of the human placentas the subpopulation of M1, important effector cells, and M2 macrophages, immunoregulatory cells.
METHODS
Sixteen cases of VUE and three control placentas were examined using immunohistochemistry with antibodies for CD3, CD68, CD11c, and CD163.
RESULTS
CD11c appeared predominantly in the inflamed villi when compared to the normal areas (<.001). These cells corresponded to 41.2% of the macrophage population in the inflamed area and were mainly present inside the villi (36%). With regards to CD163, these cells tended to be in higher amounts in the inflamed villi when compared to CD11c and normal areas.
DISCUSSION
We conclude that the almost exclusive presence of M1 macrophages in the inflamed areas suggests the influence of these cells in the pathogenesis VUE. The greater amount of M2 in villitis and normal areas suggests a possible immunoregulatory mechanism of the inflammatory process in VUE.
简介
胎盘绒毛膜炎的特征是胎盘绒毛中有炎症浸润。本研究的目的是描述原因不明的胎盘绒毛膜炎（VUE）中 M1 型，即重要效应细胞，和 M2 型巨噬细胞的免疫调节细胞的特征。
方法
使用针对 CD3、CD68、CD11c 和 CD163 的免疫组化检测 16 例 VUE 病例和 3 例对照胎盘。
结果
与正常区域相比，CD11c 在炎症绒毛中更为明显（<0.001）。这些细胞在炎症区域的巨噬细胞群体中占 41.2%，主要存在于绒毛内（36%）。关于 CD163，与 CD11c 和正常区域相比，这些细胞在炎症绒毛中的含量更高。
讨论
我们得出结论，几乎只存在于炎症区域的 M1 巨噬细胞表明这些细胞在 VUE 发病机制中的影响。在绒毛膜炎和正常区域中 M2 数量较多表明 VUE 炎症过程可能存在免疫调节机制。
Zotero 插件