Fisher D R, Hendry J H
Radiobiology Department, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.
Radiat Res. 1988 Jan;113(1):51-7.
The sensitivity to X-ray dose fractionation was assessed for hepatocytes forming colonies in fat pads in mice. When the cells were assayed 1 day after the last irradiation the alpha/beta ratio was 1.0-1.6 depending on the method of analysis. The alpha/beta ratio describing the shape of the single-dose survival curve was much higher, and it did not predict the response to fractionation. When the assay was delayed for 10 months after the fractionated irradiation, the alpha/beta ratio was 1.9-2.1, and the beta component showed the greatest change with time. It is concluded that hepatocytes respond to dose fractionation in a manner expected of a late-responding tissue, even when the cells are assayed as early as 1 day after the last dose.
对在小鼠脂肪垫中形成集落的肝细胞的X射线剂量分割敏感性进行了评估。当在最后一次照射后1天对细胞进行检测时，根据分析方法，α/β比值为1.0 - 1.6。描述单剂量存活曲线形状的α/β比值要高得多，并且它不能预测对分割照射的反应。当在分割照射后延迟10个月进行检测时，α/β比值为1.9 - 2.1，并且β分量随时间变化最大。得出的结论是，即使在最后一剂后最早1天就对细胞进行检测，肝细胞对剂量分割的反应方式也符合晚反应组织的预期。
