血小板平均体积降低预示着胰腺癌患者预后不良。
Decreased mean platelet volume predicts poor prognosis in patients with pancreatic cancer.
机构信息
Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Department of Surgery, Japanese Red Cross Tottori Hospital, 117 Shotoku-cho, Tottori, 680-8517, Japan.
出版信息
BMC Surg. 2021 Jan 6;21(1):8. doi: 10.1186/s12893-020-00976-5.
BACKGROUND
Decreased mean platelet volume (MPV) predicts poor prognosis in some cancers. However, its significance as a prognostic indicator in pancreatic cancer (PC) remains unclear.
METHODS
A total of 91 PC patients who underwent pancreatectomy were included in this study. MPV and serum carbohydrate antigen 19-9 (CA19-9) were measured within 1 week before surgery.
RESULTS
We divided patients into MPV (≥ 8.65; n = 40), MPV (< 8.65; n = 51), CA19-9 (≥ 66.3; n = 47), and CA19-9 (< 66.3; n = 44) groups based on the optimal cut-off values determined from receiver operating characteristic curve analysis. The 5-year overall survival (OS) rates were significantly lower in the MPV than in the MPV group (16.9% and 56.3%, respectively; P = 0.0038), and the 5-year disease-specific survival (DSS) rates in the MPV group and MPV group were 20.5% and 62.2%, respectively (P = 0.0031). Multivariate analysis identified MPV as an independent prognostic indicator for both OS and DSS. The patients were then divided into groups A (MPV and CA19-9), B (MPV and CA19-9), C (MPV and CA19-9), and D (MPV and CA19-9), with 5-year OS rates of 73.2%, 40.4%, 25.8%, and 10.3%, respectively (P = 0.0002), and 5-year DSS rates of 80.8%, 44.9%, 27.3%, and 16.4%, respectively (P = 0.0003).
CONCLUSIONS
Classification based on MPV and CA19-9 might be useful for predicting long-term outcomes in patients with PC.
背景
血小板平均体积（MPV）降低预示着某些癌症预后不良。然而，其作为胰腺癌（PC）预后指标的意义尚不清楚。
方法
本研究共纳入 91 例行胰腺切除术的 PC 患者。在手术前 1 周内测量了 MPV 和血清糖抗原 19-9（CA19-9）。
结果
根据受试者工作特征曲线分析确定的最佳截断值，我们将患者分为 MPV（≥8.65；n=40）、MPV（<8.65；n=51）、CA19-9（≥66.3；n=47）和 CA19-9（<66.3；n=44）组。MPV 组的 5 年总生存率（OS）明显低于 MPV 组（分别为 16.9%和 56.3%；P=0.0038），MPV 组和 MPV 组的 5 年疾病特异性生存率（DSS）分别为 20.5%和 62.2%（P=0.0031）。多因素分析表明，MPV 是 OS 和 DSS 的独立预后指标。然后，将患者分为 A（MPV 和 CA19-9）、B（MPV 和 CA19-9）、C（MPV 和 CA19-9）和 D（MPV 和 CA19-9）组，5 年 OS 率分别为 73.2%、40.4%、25.8%和 10.3%（P=0.0002），5 年 DSS 率分别为 80.8%、44.9%、27.3%和 16.4%（P=0.0003）。
结论
基于 MPV 和 CA19-9 的分类可能有助于预测 PC 患者的长期预后。
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