Kumagai Shogo, Tokuno Junko, Ueda Yuichiro, Marumo Satoshi, Shoji Tsuyoshi, Nishimura Takafumi, Fukui Motonari, Huang Cheng-Long
Respiratory Disease Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 530-8480, Japan.
Department of Medical Oncology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 530-8480, Japan.
Mol Clin Oncol. 2015 Jan;3(1):197-201. doi: 10.3892/mco.2014.436. Epub 2014 Oct 6.
An increased mean platelet volume (MPV) is an early marker of platelet activation. MPV was also shown to be associated with the pathophysiological characteristics of various types of cancer. A previous study demonstrated that MPV was significantly associated with the overall survival (OS) of patients with advanced non-small-cell lung cancer (NSCLC). However, there has been no analysis of the prognostic effect of MPV on patients with resected NSCLC. The aim of this study was to evaluate the contribution of MPV to the survival of patients with completely resected NSCLC. We retrospectively analyzed 308 consecutive patients with NSCLC who underwent curative resection at Kitano Hospital. The associations between MPV and clinicopathological factors were assessed. We also evaluated the effect of MPV on survival, using the two-tailed log-rank test and the Cox proportional hazards model. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. A low MPV was not associated with any other clinicopathological factors. The two-tailed log-rank test demonstrated that patients with a low MPV experienced a shorter disease-free survival (DFS) and overall survival (OS) (P=0.011 and 0.001, respectively), compared to those with a high MPV. The multivariate analysis demonstrated that a low MPV was an independent unfavorable prognostic factor for DFS and OS [hazard ratio (HR)=1.713; 95% confidence interval (CI): 1.070-2.742, P=0.025; and HR=2.835; 95% CI: 1.304-6.163, P=0.009, respectively)]. Therefore, we demonstrated that a low MPV predicted an unfavorable prognosis in patients with NSCLC following curative resection.
平均血小板体积（MPV）升高是血小板活化的早期标志物。MPV还被证明与各类癌症的病理生理特征相关。先前的一项研究表明，MPV与晚期非小细胞肺癌（NSCLC）患者的总生存期（OS）显著相关。然而，尚未有关于MPV对接受手术切除的NSCLC患者预后影响的分析。本研究的目的是评估MPV对完全切除的NSCLC患者生存的影响。我们回顾性分析了在北野医院接受根治性切除的308例连续NSCLC患者。评估了MPV与临床病理因素之间的关联。我们还使用双侧对数秩检验和Cox比例风险模型评估了MPV对生存的影响。MPV值8.50 fl被认为是预后的最佳临界值。低MPV与任何其他临床病理因素均无关联。双侧对数秩检验表明，与高MPV患者相比，低MPV患者的无病生存期（DFS）和总生存期（OS）较短（分别为P = 0.011和0.001）。多变量分析表明，低MPV是DFS和OS的独立不良预后因素[风险比（HR）= 1.713；95%置信区间（CI）：1.070 - 2.742，P = 0.025；以及HR = 2.835；95% CI：1.304 - 6.163，P = 0.009]。因此，我们证明低MPV预示着根治性切除术后NSCLC患者的预后不良。
