Roddie M E, Peters A M, Danpure H J, Osman S, Henderson B L, Lavender J P, Carroll M J, Neirinckx R D, Kelly J D
Department of Diagnostic Radiology, Hammersmith Hospital, London, England.
Radiology. 1988 Mar;166(3):767-72. doi: 10.1148/radiology.166.3.3340775.
Leukocytes labeled with technetium-99m hexamethylpropyleneamine oxime (HMPAO) were used in 100 patients: 32 with suspected inflammatory bowel disease, 17 with fever of unknown origin, 21 with suspected abdominal sepsis, 20 with suspected bone sepsis, seven with bronchiectasis, and three with recent myocardial infarction. The distribution of activity in patients subsequently shown not to have inflammatory bowel disease was similar to that previously described for indium-111-labeled leukocytes. However, in this study, activity was also seen in the kidneys and bladder and occasionally the gallbladder on both early (1-3 hours) and late (24 hours) views, and in the colon in late views. Migration of Tc-99m-labeled granulocytes was seen in inflammatory disease as early as 30 minutes after injection, while normal bowel activity was not seen before 4 hours. The sensitivity of Tc99m-labeled leukocytes in the detection of inflammation was 100%, the specificity was 95%.
100例患者使用了用锝-99m六甲基丙烯胺肟（HMPAO）标记的白细胞：32例疑似炎症性肠病患者、17例不明原因发热患者、21例疑似腹部脓毒症患者、20例疑似骨脓毒症患者、7例支气管扩张患者和3例近期心肌梗死患者。随后显示没有炎症性肠病的患者的活性分布与先前描述的铟-111标记的白细胞相似。然而，在本研究中，在早期（1至3小时）和晚期（24小时）图像上，肾脏、膀胱以及偶尔胆囊中也可见活性，晚期图像上结肠中也可见活性。注射后30分钟在炎症性疾病中即可见到锝-99m标记的粒细胞迁移情况，而正常肠道活性在4小时之前未见。锝-99m标记的白细胞检测炎症的敏感性为100%，特异性为95%。
