Department of Biostatistics and Epidemiology, Social Determinants of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.
Syst Rev. 2021 Jan 6;10(1):10. doi: 10.1186/s13643-020-01560-x.
Symptoms in multiple sclerosis (MS) can lead to different types and ranges of sexual dysfunction in MS patients. Studies in different parts of the world have reported a high range of sexual dysfunction in men with MS. This study aimed to estimate pooled prevalence of sexual dysfunction in men with MS.
The authors searched Web of Science, PubMed, Scopus, Embase, Magiran, SID, and Iran Medical Papers Database using the keywords "multiple sclerosis", "sexual dysfunctions", "men", "prevalence", and their synonyms systematically. Meta-analysis was performed using the random effects model with inverse variance-weighted method to estimate the overall prevalence of sexual dysfunction in men with MS. The protocol for this meta-analysis is available in PROSPERO (ID CRD42020199005).
A total of 351 documents were identified, and 20 articles published from 1996 to 2019 were analyzed. The articles used sample sizes from 9 to 101 individuals. However, two studies conducted online used 388 and 1568 samples. Prevalence of sexual dysfunction in all studies was reported from 31 to 92%, and the pooled prevalence of sexual dysfunction in men with MS in all studies was 62.9% with a 95% confidence interval 53 to 72.7% (heterogeneity: I = 96.3%, Q-statistic = 12.48, P value < 0.001). According to the results of Egger's test, there was publication bias in the current study (β = 4.55, Se = 1.38, P value = 0.004).
Sexual dysfunction is highly prevalent in men with MS. Diagnosing sexual dysfunction in MS patients in clinics by specialists have to be considered a necessity.
多发性硬化症（MS）的症状可导致 MS 患者出现不同类型和程度的性功能障碍。世界各地的研究报告称，MS 男性的性功能障碍发生率较高。本研究旨在评估 MS 男性性功能障碍的综合患病率。
作者系统地使用“多发性硬化症”、“性功能障碍”、“男性”、“患病率”及其同义词，在 Web of Science、PubMed、Scopus、Embase、Magiran、SID 和伊朗医学文献数据库中搜索文献。采用随机效应模型，使用逆方差加权法进行荟萃分析，以估计 MS 男性性功能障碍的总体患病率。本荟萃分析的方案可在 PROSPERO（ID CRD42020199005）中获得。
共检索到 351 篇文献，分析了 1996 年至 2019 年发表的 20 篇文章。这些文章的样本量从 9 到 101 不等。然而，有两项在线研究的样本量分别为 388 和 1568。所有研究均报道了性功能障碍的患病率为 31%至 92%，所有研究中 MS 男性性功能障碍的综合患病率为 62.9%，95%置信区间为 53%至 72.7%（异质性：I = 96.3%，Q 统计量 = 12.48，P 值 < 0.001）。根据 Egger 检验的结果，本研究存在发表偏倚（β = 4.55，Se = 1.38，P 值 = 0.004）。
性功能障碍在 MS 男性中普遍存在。专科医生在诊所中诊断 MS 患者的性功能障碍必须被视为必要。
