Azimi Amirreza, Hanaei Sara, Sahraian Mohammad Ali, Mohammadifar Mehdi, Ramagopalan Sreeram V, Ghajarzadeh Mahsa
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Immunodeficiencies (RCID), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Maedica (Bucur). 2019 Dec;14(4):408-412. doi: 10.26574/maedica.2019.14.4.408.
Sexual dysfunction (SD) is an important issue for women suffering from multiple sclerosis (MS). There is a discrepancy among the reported prevalence of SD in studies that were conducted in different geographical regions. We aimed to conduct this systematic review and meta-analysis to estimate pooled prevalence of SD in women with MS. We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, Google Scholar and gray literature, including references of selected studies and conference abstracts that were published up to April 2019. The search strategy included MeSH and text words as (sexual function) OR (sexual dysfunction) AND (Multiple Sclerosis OR Sclerosis, Multiple) OR (Sclerosis, Disseminated) OR (Disseminated Sclerosis) OR (MS) (Multiple Sclerosis) OR (Multiple Sclerosis, Acute Fulminating) AND (Female Sexual Function Index OR FSFI). Two independent researchers independently assessed the articles. The literature search found 168 articles but only nine were considered for the final analysis. Two studies were from Greece, three from Iran, one from Turkey, one from Poland, one from Germany and one from Italy. In total, 1060 MS cases were analyzed. The prevalence of SD was extremely discrepant, from 27% to 95%, and the pooled estimate was calculated as 55% (95% CI 41%-69%), (I²=96.3%, P<00.1). Prevalence of SD is discrepant among women with MS in different countries and it should be considered as an important concern.
性功能障碍（SD）是患有多发性硬化症（MS）的女性面临的一个重要问题。在不同地理区域开展的研究中，所报告的SD患病率存在差异。我们旨在进行这项系统评价和荟萃分析，以估计MS女性中SD的合并患病率。我们检索了PubMed、Scopus、EMBASE、CINAHL、Web of Science、Ovid、谷歌学术以及灰色文献，包括截至2019年4月发表的所选研究的参考文献和会议摘要。检索策略包括医学主题词（MeSH）和文本词，如（性功能）或（性功能障碍）以及（多发性硬化症或硬化症，多发性）或（播散性硬化症）或（播散性硬化）或（MS）（多发性硬化症）或（急性暴发性多发性硬化症）以及（女性性功能指数或FSFI）。两名独立研究人员独立评估文章。文献检索发现168篇文章，但最终分析仅纳入9篇。两项研究来自希腊，三项来自伊朗，一项来自土耳其，一项来自波兰，一项来自德国，一项来自意大利。总共分析了1060例MS病例。SD的患病率差异极大，从27%到95%，合并估计值计算为55%（95%CI 41%-69%），（I²=96.3%，P<0.01）。不同国家MS女性中SD的患病率存在差异，应将其视为一个重要问题。
