Xuan Xiuyun, Zhang Lin, Tian Chunxia, Wu Ting, Ye Haihua, Cao Juanmei, Chen Fangqi, Liang Yan, Yang Huilan, Huang Changzheng
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.
Department of Gerontology, Jinan City People's Hospital, Jinan, 271199, Shandong, China.
Cell Biosci. 2021 Jan 6;11(1):2. doi: 10.1186/s13578-020-00504-1.
Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling pathway. It has recently been reported that IL-22 also contributes to the pathogenesis of many connective tissue diseases (CTDs). In this review, we will discuss the role of IL-22 in several CTDs, such as system lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, systemic sclerosis and dermatomyositis, suggesting that IL-22 may be a potential therapeutic target in CTDs.
白细胞介素-22(IL-22)是细胞因子IL-10家族的成员之一,由参与机体免疫微环境的多种免疫细胞产生。IL-22通过与IL-22受体复合物(IL-22R)结合,随后激活IL-22R下游信号通路发挥其关键作用。最近有报道称,IL-22也参与了许多结缔组织病(CTD)的发病机制。在本综述中,我们将讨论IL-22在几种CTD中的作用,如系统性红斑狼疮、类风湿性关节炎、干燥综合征、系统性硬化症和皮肌炎,提示IL-22可能是CTD的一个潜在治疗靶点。