Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
College of Dentistry, University of Florida, Gainesville, FL, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Apr;131(4):422-427. doi: 10.1016/j.oooo.2020.12.001. Epub 2020 Dec 16.
This article reviews the literature and evidence of the association of medication-related osteonecrosis of the jaw with tumor necrosis factor-α inhibition.
A systematic review was performed using electronic databases (PubMed, MEDLINE, and Embase) using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Key terms were used in the search. No restrictions were placed on publication status. Selection criteria comprised all levels of available evidence. Articles in the English language were selected up to and including July 2020. Reference lists of relevant studies were searched for additional articles. Articles were selected on the basis of inclusion and exclusion criteria. Findings from eligible studies were extracted by one reviewer and confirmed by a second. Disagreements were settled through discussion.
The initial search of the key terms yielded 2107 articles. There were 1192 articles remaining after removal of duplicates and addition of 6 articles that were hand-selected from among reference lists of relevant studies. There were 12 eligible articles after screening. The full texts were read, and 5 articles were included on the basis of inclusion and exclusion criteria.
Further research is required to determine an association of medication-related osteonecrosis of the jaw and tumor necrosis factor-α inhibition.
本文回顾了与肿瘤坏死因子-α 抑制相关的药物相关性颌骨坏死的文献和证据。
使用电子数据库（PubMed、MEDLINE 和 Embase）按照系统评价和荟萃分析的首选报告项目指南进行系统评价。搜索中使用了关键术语。未对出版物状态进行限制。选择标准包括所有可用证据水平的研究。选择截至 2020 年 7 月的英语文章。还搜索了相关研究的参考文献列表以获取其他文章。根据纳入和排除标准选择文章。由一名评审员提取合格研究的结果，并由第二名评审员确认。通过讨论解决分歧。
初始关键词搜索产生了 2107 篇文章。去除重复项并添加从相关研究参考文献中手动选择的 6 篇文章后，还剩 1192 篇文章。筛选后有 12 篇符合条件的文章。阅读全文后，根据纳入和排除标准纳入了 5 篇文章。
需要进一步研究以确定药物相关性颌骨坏死与肿瘤坏死因子-α 抑制之间的关联。
