足月健康印度婴儿从出生到 2 岁时的追赶生长和减速生长：一项前瞻性队列研究。

Catch-up and Catch-down Growth in Term Healthy Indian Infants From Birth to Two Years: A Prospective Cohort Study.

机构信息

Pediatric Endocrinology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Correspondence to: Dr Vandana Jain, Professor, Pediatric Endocrinology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Pediatric Endocrinology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian Pediatr. 2021 Apr 15;58(4):325-331. Epub 2021 Jan 2.

PMID:33408281

Abstract

BACKGROUND

Catch-up in the first two years of life may help in reducing the growth deficit.

OBJECTIVE

To study growth pattern of term infants from birth to 2 years, focusing on catch-up and catch-down growth (increase or decrease in z-score >0.67) in weight and length.

STUDY DESIGN

Prospective birth cohort.

PARTICIPANTS

262 healthy term infants with birthweight 1800-4000 g.

INTERVENTION

Serial assessment of anthropometric parameters at birth, 3.5 month, 1 year and 2 year of age.

OUTCOMES

Proportion, timing and determinants of catch-up and catch-down growth.

RESULTS

Weight catch-up between birth to 3.5 mo, 1 y, and 2 y was seen in 18%, 41% and 38%; and weight catch-down in 27%, 25% and 23%, respectively. Between birth and 2 y, change in weight z-score was inversely related to birthweight (b -3.754, P<0.001) and directly to caloric intake at 2 y (b 0.003, P<0.001). Mean (SD) birthweights of infants with catch-up, steady growth and catch-down were 2.6 (0.4), 2.9 (0.4) and 3.1 (0.4) kg, respectively (P<0.001). Catch-up and catch-down in length between birth and 2 y were present in 30% and 33% of the infants, respectively. Length z-scores at 2 y but not at birth were positively correlated with mothers' (r=0.21, P=0.002) and fathers' height (r=0.22, P=0.001).

CONCLUSIONS

Nearly two-thirds of healthy term infants experienced either catch-up or catch-down in weight and length first 2 years of life. Infants' birthweight and length at birth, caloric intake, and parents' heights are important determinants of their growth patterns.

摘要

背景

生命最初两年的追赶生长有助于减少生长不足。

目的

研究足月婴儿从出生到 2 岁的生长模式，重点关注体重和身长的追赶生长（体重和身长 Z 评分增加或减少>0.67）和追赶生长（体重和身长 Z 评分增加或减少>0.67）。

研究设计

前瞻性出生队列研究。

参与者

262 名出生体重 1800-4000 克的健康足月婴儿。

干预

在出生时、3.5 个月、1 岁和 2 岁时对人体测量参数进行连续评估。

结果

体重在出生至 3.5 个月、1 岁和 2 岁时出现追赶生长的比例分别为 18%、41%和 38%；体重在 27%、25%和 23%时出现追赶生长。从出生到 2 岁，体重 Z 评分的变化与出生体重呈负相关（b=-3.754，P<0.001），与 2 岁时的热量摄入呈正相关（b=0.003，P<0.001）。追赶生长、稳定生长和追赶生长婴儿的平均（SD）出生体重分别为 2.6（0.4）、2.9（0.4）和 3.1（0.4）kg，差异有统计学意义（P<0.001）。出生至 2 岁时，体重和身长均出现追赶生长和追赶生长的婴儿分别占 30%和 33%。2 岁时的身长 Z 评分与母亲身高呈正相关（r=0.21，P=0.002），与父亲身高呈正相关（r=0.22，P=0.001），但与出生时的身长 Z 评分无相关性。