芳香烃受体与肠脑轴。
The aryl hydrocarbon receptor and the gut-brain axis.
机构信息
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
出版信息
Cell Mol Immunol. 2021 Feb;18(2):259-268. doi: 10.1038/s41423-020-00585-5. Epub 2021 Jan 6.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut-brain axis and its potential value as a therapeutic target for immune-mediated diseases.
芳香烃受体 (AHR) 是一种配体激活的转录因子，最初被鉴定为二恶英的受体。在发现后的近半个世纪，AHR 现在被认为是多种生理配体的受体，在健康和疾病中发挥着重要作用。在这篇综述中，我们讨论了 AHR 在肠脑轴中的作用及其作为免疫介导性疾病治疗靶点的潜在价值。
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