Winkowski Mateusz, Stacewicz Tadeusz
Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw, Poland.
Biomed Opt Express. 2020 Nov 10;11(12):7019-7031. doi: 10.1364/BOE.405384. eCollection 2020 Dec 1.
The optical detector of formaldehyde designed for sensing cancer biomarkers in air exhaled from human lungs with possible application in free atmosphere is described. The measurements were performed at wavelengths ranging from 3595.77-3596.20 nm. It was stated that at the pressure of 0.01 atm this absorption band exhibits the best immunity to typical interferents that might occur at high concentration in human breath. Multipass absorption spectroscopy was also applied. The method of optical fringes quenching by wavelength modulation and signal averaging over the interferences period was presented. The application of such approaches enabled the detection limit of about single ppb to be achieved.
描述了一种用于检测人呼出气体中癌症生物标志物的甲醛光学探测器，该探测器可能应用于自由大气环境。测量在3595.77 - 3596.20纳米的波长范围内进行。据称，在0.01个大气压下，该吸收带对人类呼吸中可能高浓度出现的典型干扰物具有最佳的抗干扰能力。还应用了多程吸收光谱法。提出了通过波长调制消除光学条纹以及在干扰期进行信号平均的方法。应用这些方法能够实现约单ppb的检测限。
