Jiao Luguang, Wang Chao, Zhang Kaizeng, Wang Jiarui, Yang Zaifu
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Biomed Opt Express. 2020 Nov 16;11(12):7165-7174. doi: 10.1364/BOE.409387. eCollection 2020 Dec 1.
There is increasing use of mid-infrared optical parametric oscillator radiation operating in the wavelength range of 3-5 µm. To expand existing damage data for skin exposure to lasers in this wavelength region, the damage threshold at the wavelength of 3.743 µm was determined in a Guizhou miniature pig model for an exposure duration of 1.0 s. The irradiance of the laser spot was nearly Gaussian-distributed and the 1/e beam diameter on the animal skin surface was fixed at 0.94 and 0.88 cm along horizontal and vertical directions. Damage lesion determinations were performed at 1- and 24-hour post-exposure. The probit analysis was employed to establish the ED values. The ED expressed in peak radiant exposure for the Gaussian spot was 4.04 J/cm at the 24-hour post-exposure. Sufficient margin existed between the damage threshold and MPE from the current laser safety standard. The obtained data may contribute to the knowledge base for refinement of laser safety standard in the wavelength range of 2.6-1000 µm.
波长范围在3 - 5 µm的中红外光学参量振荡器辐射的应用越来越广泛。为了扩充皮肤在该波长区域暴露于激光的现有损伤数据，在贵州小型猪模型中测定了波长为3.743 µm、暴露持续时间为1.0 s时的损伤阈值。激光光斑的辐照度近似高斯分布，动物皮肤表面的1/e束直径在水平和垂直方向分别固定为0.94 cm和0.88 cm。在暴露后1小时和24小时进行损伤病变判定。采用概率分析来确定有效剂量（ED）值。暴露后24小时，高斯光斑的峰值辐射暴露所表示的ED值为4.04 J/cm²。损伤阈值与现行激光安全标准中的最大允许暴露量（MPE）之间存在足够的余量。所获得的数据可能有助于完善2.6 - 1000 µm波长范围内激光安全标准的知识库。
