Sharma Priyamvada, Shivhare Parul, Marimutthu P, Sharma Manoj Kumar, Murthy Pratima
Department of Clinical Psychopharmacology & Neurotoxicology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
J Family Med Prim Care. 2020 Oct 30;9(10):5252-5255. doi: 10.4103/jfmpc.jfmpc_698_20. eCollection 2020 Oct.
Caffeine use and abuse is a concern among treatment seekers for psychological problems. This aspect has not been documented an Indian context as well as its relevance in primary care setting. The aim of the present study was to explore and compare the caffeine intake and prevalence in Indian psychiatric patients and healthy subjects.
Caffeine analysis in urine samples was carried out using a gold technique, gas chromatograph and mass selective detectors. This analytical technique is highly sensitive for identification of unambiguous compound. Two hundred and forty-three subjects having psychiatric disorders, along with forty-two healthy subjects were included in the study. They were assessed by using structured interview for caffeine use and screened for substance dependence as well.
One hundred twenty-eight subjects had history of substance use along with other comorbid psychiatric problems The mean of caffeine values was 1459 ± 1140 ng/mL, Whereas 42 subjects in control group (male 26, female 16) in the age group of 21-60 years had the mean caffeine levels of 1023 ± 788.8 ng/mL. The Caffeine use was significantly higher ( ≥ 0.84) in the subjects with psychiatric problems in comparison to the healthy subjects.
It implies the need to enable and sensitize the primary care physicians in screening and educating treatment seekers with psychiatric morbidities for the management of caffeine use.
咖啡因的使用和滥用是寻求心理问题治疗者所关注的问题。在印度背景下,这一方面尚未有文献记载,其在初级保健环境中的相关性也未得到研究。本研究的目的是探索和比较印度精神病患者和健康受试者的咖啡因摄入量及患病率。
采用金技术、气相色谱仪和质量选择检测器对尿液样本进行咖啡因分析。这种分析技术对明确化合物的鉴定具有高度敏感性。本研究纳入了243名患有精神疾病的受试者以及42名健康受试者。通过结构化访谈评估他们的咖啡因使用情况,并对物质依赖进行筛查。
128名受试者有物质使用史以及其他共病精神问题。咖啡因值的均值为1459±1140纳克/毫升,而年龄在21 - 60岁的对照组中的42名受试者(男性26名,女性16名)的咖啡因水平均值为1023±788.8纳克/毫升。与健康受试者相比,患有精神问题的受试者的咖啡因使用量显著更高(≥0.84)。
这意味着有必要使初级保健医生具备筛查能力并提高其意识,对患有精神疾病的治疗寻求者进行咖啡因使用管理方面的教育。