初发未用药的精神分裂症患者外周血淋巴细胞中外显子II的异常可变剪接。
Aberrant alternative splicing of exon II in peripheral blood lymphocytes of drug-naïve schizophrenic patients.
作者信息
Grunina Maria N, Belinskaia Mariia A, Zhuravlev Alexander S, Nasyrova Regina F, Krupitsky Evgeny M, Taraskina Anastasiya E, Zabotina Anna M
机构信息
Laboratory of Molecular Human Genetics, Petersburg Nuclear Physics Institute Named by B.P.Konstantinov of National Research Centre "Kurchatov Institute", 1 Microdistrict Orlova roshcha, Leningradskaya Oblast, Gatchina, 188300, Russia.
Department of Personalized Psychiatry and Neurology and Department of Addiction, V.M. Bekhterev National Medical Research Center Psychiatry and Neurology, ul. Bekhterev 3, Saint Petersburg, 192019, Russia.
出版信息
Heliyon. 2020 Dec 24;6(12):e05809. doi: 10.1016/j.heliyon.2020.e05809. eCollection 2020 Dec.
The aim of the study was to characterize the pattern of transcript isoforms of exon II in lymphocytes of the blood as peripheral biomarkers of schizophrenia development and the effectiveness of antipsychotic therapy. We primarily observed an increase in mRNA levels and elevation of alternative variants in a sample of drug-naïve schizophrenic patients compared to the control group. There was no association of the expression level of transcript isoforms with the effectiveness of the antipsychotic therapy. Antipsychotic-induced akathisia was associated with a significant reduction in the mRNA levels of the studied isoforms. In summary, our results suggest that levels of HTR2A exon II transcript isoforms are upregulated in patients with schizophrenia, but at the same time, elevated expression level of the studied transcripts is associated with fewer side effects of the therapy.
本研究的目的是将血液淋巴细胞中外显子II的转录异构体模式表征为精神分裂症发展的外周生物标志物以及抗精神病治疗的有效性。与对照组相比，我们主要观察到未使用过药物的精神分裂症患者样本中mRNA水平的增加和可变变体的升高。转录异构体的表达水平与抗精神病治疗的有效性之间没有关联。抗精神病药物引起的静坐不能与所研究异构体的mRNA水平显著降低有关。总之，我们的结果表明，精神分裂症患者中HTR2A外显子II转录异构体的水平上调，但同时，所研究转录本的表达水平升高与治疗的副作用较少有关。
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