奥拉伊通道：钙稳态的关键参与者。

Orai channels: key players in Ca homeostasis.

作者信息

Sallinger Matthias, Berlansky Sascha, Frischauf Irene

机构信息

Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Austria.

出版信息

Curr Opin Physiol. 2020 Oct;17:42-49. doi: 10.1016/j.cophys.2020.06.006. Epub 2020 Jun 29.

DOI:10.1016/j.cophys.2020.06.006

PMID:33409426

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7116546/

Abstract

Maintaining a precise calcium (Ca) balance is vital for cellular survival. The most prominent pathway to shuttle Ca into cells is the Ca release activated Ca (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca entry. This short review traces the latest articles published in the field of CRAC channel signalling with a focus on the structure of the pore-forming Orai proteins, the propagation of the binding signal from STIM1 through the channel to the central pore and their role in human health and disease.

摘要

维持精确的钙（Ca）平衡对细胞存活至关重要。将Ca转运到细胞内最主要的途径是钙释放激活钙（CRAC）通道。Orai蛋白是这一钙内流核心机制中不可或缺的参与者。这篇简短的综述追溯了CRAC通道信号领域发表的最新文章，重点关注形成孔道的Orai蛋白的结构、从基质相互作用分子1（STIM1）通过通道到中央孔道的结合信号的传播，以及它们在人类健康和疾病中的作用。