Morand Susan, Stanbery Laura, Walter Adam, Rocconi Rodney P, Nemunaitis John
Department of Internal Medicine, University of Toledo, Toledo, OH, USA.
Gradalis, Inc, Carrollton, TX, USA.
JNCI Cancer Spectr. 2020 Aug 24;4(6):pkaa077. doi: 10.1093/jncics/pkaa077. eCollection 2020 Dec.
BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation.
BRCA1 以及可能的 BRCA2 蛋白可能与自噬的调节有关。从肿瘤和免疫效应细胞的角度来看，自噬在免疫反应中起着关键作用。在存在突变的细胞中，自噬增加会导致主要组织相容性复合体 II 类分子的表达升高，但可能会引起亚克隆新抗原呈递，这可能会损害与克隆新抗原可见性相关的免疫反应。我们综述了 BRCA1/2 对自噬、免疫反应和抗原呈递调节的相关证据。
