Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, China.
Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, China.
Neurol Sci. 2021 Aug;42(8):3383-3387. doi: 10.1007/s10072-020-04949-7. Epub 2021 Jan 7.
This study aims to compare the levels of NLRP3 inflammasome and its related cytokines (IL-1β, IL-6, and IL-17), in serum and cerebrospinal fluid (CSF) of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), non-inflammatory chronic polyneuropathy, and functional neurological disorders. The results showed elevated NLRP3 inflammasome, IL-1β, IL-6, and IL-17 levels in serum but not in CSF of CIDP, compared to the other groups. Moreover, there was a positive correlation between NLRP3 inflammasome level and each cytokine. We also found a positive correlation between serum NLRP3 inflammasome level and disease severity in CIDP patients. Taken together, these results suggested that NLRP3 inflammasome could act as a potential biomarker to diagnose CIDP and assess the severity of the disease.
本研究旨在比较 NLRP3 炎性体及其相关细胞因子（IL-1β、IL-6 和 IL-17）在慢性炎症性脱髓鞘性多发性神经病（CIDP）、非炎症性慢性多发性神经病和功能性神经障碍患者血清和脑脊液（CSF）中的水平。结果显示，与其他组相比，CIDP 患者血清中 NLRP3 炎性体、IL-1β、IL-6 和 IL-17 水平升高，但 CSF 中无此变化。此外，NLRP3 炎性体水平与每种细胞因子之间呈正相关。我们还发现 CIDP 患者血清 NLRP3 炎性体水平与疾病严重程度呈正相关。综上所述，这些结果表明 NLRP3 炎性体可作为潜在的生物标志物用于诊断 CIDP 并评估疾病的严重程度。
