Gray L E, Rogers J M, Ostby J S, Kavlock R J, Ferrell J M
Reproductive Toxicology Branch, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Toxicol Appl Pharmacol. 1988 Feb;92(2):266-73. doi: 10.1016/0041-008x(88)90386-9.
Exposure to the fungicide dinocap during gestation produces behavioral abnormalities in the house mouse that are not apparent at birth but become obvious at weaning. Pregnant mice (CD-1) were exposed on Days 7 to 16 of gestation to dinocap at 0, 6, 12, or 25 mg/kg/day and the postnatal behavioral development of the offspring was assessed. Torticollis (head-tilting) appears in the treated offspring at 3 weeks of age (4.4% at 12 and 25.3% at 25 mg/kg/day) and, during a test of swimming ability, many of the mice (6.8% at 12 and 47.2% at 25 mg/kg/day) sink below the surface or are unstable and swim on their side in the water. These behavioral abnormalities are the result of agenesis of the otoliths in the inner ears. These were the only developmental defects noted in the 12 mg/kg/day dosage group. In this group 4.4% of the mice displayed torticollis, 9.2% did not swim normally, 19% were missing one or more whole otoliths (7.7% were missing all four otoliths), and partial agenesis of the crystalline material was seen in an additional 11.6% of the mice. The frequency of behavioral and inner ear defects increased in the higher dosage group, but the order of sensitivity of the effects did not change.
孕期接触杀真菌剂敌菌丹会使家鼠出现行为异常，这些异常在出生时并不明显，但在断奶时会变得明显。将怀孕的小鼠（CD-1）在孕期第7至16天暴露于0、6、12或25毫克/千克/天的敌菌丹中，并评估后代的产后行为发育。斜颈（头部倾斜）出现在3周龄的经处理后代中（12毫克/千克/天组为4.4%，25毫克/千克/天组为25.3%），并且在游泳能力测试中，许多小鼠（12毫克/千克/天组为6.8%，25毫克/千克/天组为47.2%）会沉入水面以下或不稳定，在水中侧游。这些行为异常是内耳耳石发育不全的结果。这些是在12毫克/千克/天剂量组中观察到的仅有的发育缺陷。在该组中，4.4%的小鼠表现出斜颈，9.2%游泳不正常，19%缺失一个或多个完整耳石（7.7%缺失全部四个耳石），另外11.6%的小鼠出现晶状体物质部分发育不全。行为和内耳缺陷的频率在较高剂量组中增加，但效应的敏感顺序没有改变。
