基于外切酶 III 和 DNA zyme 的 COVID-19 检测双识别元件控制逻辑 DNA 电路。
Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme.
机构信息
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China.
National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China.
出版信息
Chem Commun (Camb). 2021 Feb 2;57(9):1125-1128. doi: 10.1039/d0cc06799g.
Two fragments of the COVID-19 genome (specific and homologous) were used as two inputs to construct an AND logic gate for COVID-19 detection based on exonuclease III and DNAzyme. The detection sensitivity of the assay can reach fM levels. Satisfactory recovery values were obtained in real sample analysis.
两段 COVID-19 基因组片段（特异性和同源性）被用作构建基于外切酶 III 和 DNA 酶的 COVID-19 检测的与门逻辑门的两个输入。该测定的检测灵敏度可达到 fM 水平。在实际样品分析中获得了令人满意的回收值。
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