Department of Woman, Child and Neonate, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", University of Milan, Milan, Italy.
Arch Gynecol Obstet. 2021 Aug;304(2):337-344. doi: 10.1007/s00404-020-05948-x. Epub 2021 Jan 7.
To evaluate fetal ventricular diastolic function in pregnancies of women with gestational diabetes (GD), to determine whether minimal anomalies of glucose metabolism may influence fetal cardiac function.
Fetal ventricular filling time was measured by transabdominal ultrasound in singleton pregnancies between 34 and 37 weeks of gestation. We used a measurement which consists in the ratio between the diastolic time and the whole cardiac cycle time.
The study included 35 women with a GD and 217 non-diabetic. Right ventricular filling time (RVFT) was significantly lower in the GD group (mean of RVFT = 39.2 ± 4.4 vs 43.6 ± 4.6; p < 0.01). Likewise, left ventricular filling time (LVFT) was shorter in the GD group compared to the non-GD group, though the difference was not significant (mean of LVFT = 43.6 ± 4.6 vs 44.6 ± 5.5; p = 0.33).
Fetal right cardiac function is altered also in pregnancies where gestational diabetes is well controlled.
评估患有妊娠期糖尿病（GD）孕妇的胎儿心室舒张功能，以确定葡萄糖代谢的微小异常是否会影响胎儿的心脏功能。
在妊娠 34 至 37 周的单胎妊娠中，通过经腹部超声测量胎儿心室充盈时间。我们使用一种测量方法，即舒张时间与整个心动周期时间的比值。
该研究纳入了 35 名患有 GD 的孕妇和 217 名非糖尿病孕妇。GD 组的右心室充盈时间（RVFT）明显较低（GD 组的 RVFT 平均值为 39.2 ± 4.4，而非 GD 组为 43.6 ± 4.6；p < 0.01）。同样，GD 组的左心室充盈时间（LVFT）也短于非 GD 组，但差异无统计学意义（GD 组的 LVFT 平均值为 43.6 ± 4.6，而非 GD 组为 44.6 ± 5.5；p = 0.33）。
即使在血糖控制良好的妊娠期糖尿病孕妇中，胎儿右心功能也会发生改变。
