Department of Obstetrics and Gynecology, Loei hospital, Kut Pong, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Diab Vasc Dis Res. 2023 Jul-Aug;20(4):14791641231190531. doi: 10.1177/14791641231190531.
To compare fetal and neonatal cardiac morphology in fetuses of mothers with gestational diabetes mellitus (GDM) with the controls.
Pregnant women at average risk of GDM underwent 100-g, 3-h-OGTT at 24-28 weeks of gestation for diagnosis of GDM. Both GDM group and the control group underwent fetal echocardiography at 32-36 weeks to assess cardiac dimensions. The neonates underwent echocardiography within 48 h after birth to assess cardiac morphology.
A total of 154 pregnant women were recruited, including 60 in the GDM group and 94 in the control group. All of the study group were well controlled for GDM. Most baseline characteristics of both groups were comparable. All obstetric outcomes were not significantly different between the two groups. Morphological cardiac dimensions in the fetuses and newborns of both groups were also not significant different. Subgroup analysis in the study group showed no significantly different in cardiac morphology between the group with diet control and that of insulin control.
Fetal and neonatal cardiac morphologic changes among mothers with well-controlled GDM are not significantly different from those in the controls. It is possible that good control of maternal blood glucose can prevent fetal and neonatal cardiac abnormalities.
比较患有妊娠期糖尿病（GDM）的孕妇胎儿和新生儿的心脏形态，与对照组进行比较。
平均患有 GDM 风险的孕妇在 24-28 周的妊娠期间接受 100g、3 小时口服葡萄糖耐量试验（OGTT）以诊断 GDM。GDM 组和对照组均在 32-36 周时进行胎儿超声心动图检查以评估心脏尺寸。新生儿在出生后 48 小时内进行超声心动图检查以评估心脏形态。
共招募了 154 名孕妇，包括 60 名 GDM 组和 94 名对照组。所有研究组均对 GDM 得到良好控制。两组的大多数基线特征均相似。两组的所有产科结局均无显著差异。两组胎儿和新生儿的心脏形态学维度也没有显著差异。研究组的亚组分析显示，饮食控制组与胰岛素控制组之间的心脏形态无显著差异。
良好控制的 GDM 母亲的胎儿和新生儿心脏形态变化与对照组无显著差异。良好控制母体血糖可能预防胎儿和新生儿心脏异常。
