IRCCS Fondazione Don Carlo Gnocchi ONLUS, Via A. Capecelatro, 66, 20148, Milan, Italy.
Department of Psychology, Catholic University, Largo A. Gemelli, 1, 20123, Milan, Italy.
Neurol Sci. 2021 May;42(5):2085-2089. doi: 10.1007/s10072-020-04959-5. Epub 2021 Jan 7.
Non-motor impairment such as emotion recognition deficit in both facial and vocal expressions has been previously reported in Parkinson's disease (PD). We investigated whether the decoding of emotional prosody is impaired in PD and whether this deficit is related to striatal damage.
Fifteen PD patients and 15 healthy controls (HCs) were requested to listen to six audio tracks and to recognize the emotions expressed by a professional actor while reading a meaning-neutral sentence. All subjects also received a structural MRI examination. Volumetric measurements were extracted for the striatum, a key region involved in emotional processing and typically impaired in PD.
Decoding sadness conveyed by voice was impaired in PD compared with HC and was related to the volume of the dorsal striatum bilaterally.
The dorsal striatum is involved in the decoding of vocal negative emotions in PD.
先前有研究报道，帕金森病（PD）患者存在面部和声音表情识别等非运动损伤。本研究旨在探究 PD 患者是否存在情绪韵律解码障碍，以及这种障碍是否与纹状体损伤有关。
15 名 PD 患者和 15 名健康对照（HC）被要求聆听 6 个音轨，并识别专业演员在朗读中性句子时所表达的情绪。所有受试者还接受了结构 MRI 检查。提取纹状体的容积测量值，该区域是涉及情绪处理的关键区域，在 PD 中通常受到损伤。
与 HC 相比，PD 患者在通过声音解码悲伤时存在障碍，且与双侧背侧纹状体的体积有关。
背侧纹状体参与 PD 患者的负性嗓音情绪解码。
