Department and Clinic of Internal Diseases, Diabetology, and Nephrology, Metabolic Bone Diseases Unit, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.
Department of Paediatrcs, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
Int J Clin Pract. 2021 May;75(5):e14009. doi: 10.1111/ijcp.14009. Epub 2021 Jan 21.
The aim of the study was the assessment of clinical significance of height loss (HL) in female population.
The study cohort was recruited from GO Study. Data from 1735 postmenopausal women aged over 55 years (mean age 68.15 ± 8.16 years) were analysed.
Data on clinical risk factors for osteoporosis and fractures were collected. Bone densitometry at hip was performed using a device Prodigy (GE, USA). Height was established using stadiometer and was compared with maximal height in early adulthood.
The mean HL was 3.9 ± 3.2 cm. HL was significantly higher in women with fractures in comparison with those without fracture (4.9 ± 3.6 cm vs 3.4 ± 2.8 cm; P < .0001). HL increased with the number of fractures, and was 4.1 ± 3.2 cm, 5.3 ± 3.5 cm and 6.7 ± 4.1 cm in women with one, two and three or more fractures respectively. Women with spine fractures presented with HL higher in comparison with all the other subjects (6.3 ± 4.0 vs 3.6 ± 2.9 cm, P < .0001) and women with all non-spine fractures (6.3 ± 4.0 vs 4.0 ± 3.0 cm, P < .0001). In women with steroid use and falls, HL was significantly greater than in subjects without this factor. HL correlated significantly with age and BMI (positively) and current height (negatively). Mean T-score for FN BMD was -1.75 ± 0.9 and correlate significantly with HL (r = -.21, P < .0001). For the HL threshold above 4 cm, the fracture incidence was above 50%.
Height loss value is a simple and very informative measure describing fracture risk and functional status in postmenopausal women. HL exceeding 4 cm is related to fracture probability above 50%.
本研究旨在评估女性人群中身高损失（HL）的临床意义。
本研究队列来自 GO 研究。分析了 1735 名年龄在 55 岁以上（平均年龄 68.15±8.16 岁）的绝经后女性的数据。
收集了骨质疏松症和骨折的临床危险因素数据。使用 Prodigy（GE，美国）设备对髋关节进行骨密度测定。身高通过身高计确定，并与成年早期的最大身高进行比较。
平均 HL 为 3.9±3.2cm。与无骨折的女性相比，骨折女性的 HL 明显更高（4.9±3.6cm 比 3.4±2.8cm；P<0.0001）。HL 随骨折数量的增加而增加，分别为 4.1±3.2cm、5.3±3.5cm 和 6.7±4.1cm。有脊柱骨折的女性 HL 明显高于所有其他受试者（6.3±4.0cm 比 3.6±2.9cm，P<0.0001）和所有非脊柱骨折的女性（6.3±4.0cm 比 4.0±3.0cm，P<0.0001）。在使用类固醇和跌倒的女性中，HL 明显大于没有此因素的女性。HL 与年龄和 BMI（正相关）和当前身高（负相关）显著相关。FN BMD 的平均 T 评分为-1.75±0.9，与 HL 显著相关（r=-.21，P<0.0001）。对于 HL 超过 4cm 的阈值，骨折发生率超过 50%。
HL 值是一种简单且非常有信息量的测量方法，可描述绝经后妇女的骨折风险和功能状态。HL 超过 4cm 与骨折概率超过 50%相关。
