Kuga K, Yamaguchi I, Sugishita Y, Ito I
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Am J Cardiol. 1988 Feb 1;61(4):361-6. doi: 10.1016/0002-9149(88)90945-9.
Age-related changes of the sinus node (SN) function and the autonomic influence on the SN function were evaluated in 65 patients with sick sinus syndrome (range 14 to 84 years). Heart rate (HR), corrected SN recovery time and sinoatrial conduction time were measured before (basic) and after (intrinsic) autonomic blockade (propranolol 0.2 mg/kg plus atropine 0.04 mg/kg intravenously). Percent of autonomic chronotropies of the SN function were calculated by the following formulas: (1)--(intrinsic HR--basic HR/intrinsic HR) X 100; (2) (intrinsic corrected SN recovery time--basic corrected SN recovery time/intrinsic corrected SN recovery time) X 100; (3) (intrinsic sinoatrial conduction time--basic sinoatrial conduction time/intrinsic sinoatrial conduction time) X 100. Basic HR, basic corrected SN recovery time and basic sinoatrial conduction time did not vary with age. Intrinsic HR decreased with age, but this correlation was weak (r = -0.54, p less than 0.001). Intrinsic corrected SN recovery time and intrinsic sinoatrial conduction time tended to increase with age (r = 0.26, p less than 0.05; r = 0.29, p less than 0.05, respectively). Percent chronotropies of HR, corrected SN recovery time and sinoatrial conduction time were negative values in younger patients and positive values in elderly patients; they correlated positively with age (r = 0.59, p less than 0.001; r = 0.60, p less than 0.001; r = 0.43, p less than 0.001, respectively). Thus, the basic SN function did not change with age, while the intrinsic SN function deteriorated with age.(ABSTRACT TRUNCATED AT 250 WORDS)
对65例年龄在14至84岁之间的病态窦房结综合征患者的窦房结（SN）功能的年龄相关性变化以及自主神经对SN功能的影响进行了评估。在自主神经阻滞前（基础状态）和后（固有状态）（静脉注射普萘洛尔0.2mg/kg加阿托品0.04mg/kg）测量心率（HR）、校正的SN恢复时间和窦房传导时间。SN功能的自主变时性百分比通过以下公式计算：（1）--（固有心率 - 基础心率/固有心率）×100；（2）（固有校正的SN恢复时间 - 基础校正的SN恢复时间/固有校正的SN恢复时间）×100；（3）（固有窦房传导时间 - 基础窦房传导时间/固有窦房传导时间）×100。基础HR、基础校正的SN恢复时间和基础窦房传导时间不随年龄变化。固有心率随年龄下降，但这种相关性较弱（r = -0.54，p＜0.001）。固有校正的SN恢复时间和固有窦房传导时间倾向于随年龄增加（分别为r = 0.26，p＜0.05；r = 0.29，p＜0.05）。HR、校正的SN恢复时间和窦房传导时间的变时性百分比在年轻患者中为负值，在老年患者中为正值；它们与年龄呈正相关（分别为r = 0.59，p＜0.001；r = 0.60，p＜0.001；r = 0.43，p＜0.001）。因此，基础SN功能不随年龄变化，而固有SN功能随年龄恶化。（摘要截断于250字）
