人类免疫缺陷病毒 1 型和肺结核合并感染患者中口腔念珠菌病的患病率：系统评价和荟萃分析。
Oral candidiasis prevalence in human immunodeficiency virus-1 and pulmonary tuberculosis coinfection: A systematic review and meta-analysis.
机构信息
Department of Oral & Maxillofacial Surgery, and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Department of Stomatology, Public Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; Division of Dentistry and Stomatology of the Clinical Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
出版信息
Microb Pathog. 2021 Jan;150:104720. doi: 10.1016/j.micpath.2020.104720. Epub 2021 Jan 4.
BACKGROUND
Human immunodeficiency virus-1 (HIV-1) infected people are more likely to develop tuberculosis (TB), being the leading cause of death in HIV-1. Candida spp has emerged as potential pathogenic fungi in patients with HIV and bronchopulmonary diseases. This systematic review summarizes the available data on the occurrence of oral candidiasis (OC) in the HIV-1/pulmonary tuberculosis (pTB) coinfection.
METHODS
Articles that reported the occurrence of OC in the HIV-1-pTB coinfection were searched in eight databases. Observational studies that evaluated the association between OC and HIV-1-pTB coinfection were selected. The risk of bias was assessed using the meta-analysis of statistics assessment and review instrument (MAStARI) checklist.
RESULTS
From a total of 1858 records, after application of inclusion and exclusion criteria, six were included in the meta-analysis. Three studies were at low risk, one at moderate risk, and two at high risk of bias. Considerable heterogeneity across the studies was identified. Meta-analyses performed showed no difference in the prevalence of OC between HIV-1 patients with and without pTB coinfection (odds ratio M-H = 1.77; 95% CI = 0.69 to 4.52).
CONCLUSION
There is no association between OC and HIV-1/pTB coinfection.
PROSPERO REGISTRATION NUMBER
CRD42019128735.
背景
人类免疫缺陷病毒 1 型（HIV-1）感染者更容易患上结核病（TB），是 HIV-1 患者的主要致死原因。假丝酵母菌属已成为 HIV 感染者和支气管肺部疾病患者中具有潜在致病性的真菌。本系统综述总结了 HIV-1/肺结核（pTB）合并感染患者中口腔念珠菌病（OC）发生的现有数据。
方法
在八个数据库中检索了报道 HIV-1/pTB 合并感染中 OC 发生情况的文章。选择了评估 OC 与 HIV-1/pTB 合并感染之间关联的观察性研究。使用 meta 分析的统计评估和综述工具（MAStARI）检查表评估偏倚风险。
结果
共纳入 1858 条记录，经过纳入和排除标准的应用，有 6 项研究被纳入荟萃分析。其中 3 项研究的偏倚风险较低，1 项研究的偏倚风险为中度，2 项研究的偏倚风险较高。研究之间存在显著的异质性。荟萃分析结果显示，HIV-1 患者中 OC 的患病率与 pTB 合并感染无关（优势比 M-H = 1.77；95%CI = 0.69 至 4.52）。
结论
OC 与 HIV-1/pTB 合并感染之间无关联。
PROSPERO 注册号：CRD42019128735。
Zotero 插件