Huerta-Reyes Maira, Gaitán-Cepeda Luis A, Sánchez-Vargas Luis O
Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, Mexico.
Departamento de Medicina y Patología Oral y Maxilofacial, División de Estudios de Postgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Plants (Basel). 2022 Oct 5;11(19):2622. doi: 10.3390/plants11192622.
The oral cavity is crucial from diagnosis to adherence to HAART therapy in the HIV/AIDS population; consequently, drugs that can maintain healthy conditions in the oral cavity are necessary for patients with HIV/AIDS. (pomegranate) is a tree that has been employed extensively for centuries in the traditional medicine of ancient cultures for the treatment of a wide range of diseases, including oral and dental diseases. In recent decades, its potent anticandidal properties have been shown, especially on , the cause of the most common clinical manifestation in HIV patients. The present work contributes to the review of the anti-HIV and anticandidal properties of the plant species as involved with the oral cavity. The literature reviewed revealed that crude extracts of pomegranate and its main isolated compounds possess inhibitory activity on different HIV targets, including binding viral proteins and the three replicative HIV enzymes. In addition, in the literature reviewed, pomegranate exhibited anticandidal effects on 10 different species. Thus, pomegranate appears to be an excellent candidate to explore and incorporate into the treatment of the oral cavity of HIV/AIDS patients, in that, in addition to its pharmacological effects such as antiviral and anticandidal, pomegranate represents an easily available, inexpensive, and safe natural source.
从诊断到艾滋病病毒/艾滋病患者坚持高效抗逆转录病毒疗法（HAART），口腔都至关重要；因此，对于艾滋病病毒/艾滋病患者而言，能够维持口腔健康状况的药物是必要的。石榴是一种树，在古代文化的传统医学中已被广泛应用了几个世纪，用于治疗多种疾病，包括口腔和牙齿疾病。近几十年来，已证明其具有强大的抗念珠菌特性，尤其是对艾滋病患者最常见临床表现的病因[此处原文缺失相关内容]。本研究有助于综述石榴这种植物与口腔相关的抗艾滋病病毒和抗念珠菌特性。所综述的文献表明，石榴的粗提物及其主要分离化合物对不同的艾滋病病毒靶点具有抑制活性，包括结合病毒蛋白和三种艾滋病病毒复制酶。此外，在所综述的文献中，石榴对10种不同的念珠菌物种表现出抗念珠菌作用。因此，石榴似乎是探索并纳入艾滋病病毒/艾滋病患者口腔治疗的极佳候选物，因为除了其抗病毒和抗念珠菌等药理作用外，石榴还是一种易于获取、价格低廉且安全的天然来源。
