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骨放射性坏死:暴露的不是骨头,而是证据。

Osteoradionecrosis: Exposing the Evidence Not the Bone.

机构信息

Department of Radiation Oncology, University of Cincinnati Medical Center, Cincinnati, Ohio.

Private Practice, Cincinnati, Ohio.

出版信息

Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1206-1218. doi: 10.1016/j.ijrobp.2020.12.043. Epub 2021 Jan 4.

DOI:10.1016/j.ijrobp.2020.12.043
PMID:33412258
Abstract

Osteoradionecrosis is a relatively rare but potentially morbid and costly complication of radiation therapy for head and neck cancer. Multidisciplinary diagnosis and treatment are essential. Despite evidence guiding individual aspects of care for osteoradionecrosis, there is a lack of broad consensus on the overall diagnosis and management of this condition. This study comprehensively reviews the literature, with a focus on the past 10 years, to guide evaluation and treatment.

摘要

放射性骨坏死是头颈部癌症放射治疗后一种相对罕见但潜在的病态和昂贵的并发症。多学科诊断和治疗至关重要。尽管有证据指导放射性骨坏死护理的各个方面,但对于这种疾病的整体诊断和管理缺乏广泛共识。本研究全面回顾了文献,重点是过去 10 年的文献,以指导评估和治疗。

相似文献

1
Osteoradionecrosis: Exposing the Evidence Not the Bone.骨放射性坏死:暴露的不是骨头,而是证据。
Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1206-1218. doi: 10.1016/j.ijrobp.2020.12.043. Epub 2021 Jan 4.
2
Osteoradionecrosis of the mandible after radiotherapy for head and neck cancer: risk factors and dose-volume correlations.头颈部癌症放疗后下颌骨放射性骨坏死:危险因素和剂量-体积相关性。
Acta Oncol. 2019 Oct;58(10):1373-1377. doi: 10.1080/0284186X.2019.1643037. Epub 2019 Jul 31.
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Osteoradionecrosis of the jaws.颌骨放射性骨坏死
J Oral Maxillofac Surg. 1986 Mar;44(3):218-23. doi: 10.1016/0278-2391(86)90111-4.
4
Osteoradionecrosis of the mandible in patients with oropharyngeal carcinoma treated with intensity-modulated radiotherapy.调强放疗治疗口咽癌患者的下颌骨放射性骨坏死。
Cancer. 2017 Oct 1;123(19):3691-3700. doi: 10.1002/cncr.30803. Epub 2017 Jun 13.
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[Predictive factors for mandibular osteoradionecrosis after irradiation of head and neck cancers].[头颈部癌放疗后下颌骨放射性骨坏死的预测因素]
Cancer Radiother. 2021 Jul;25(5):484-493. doi: 10.1016/j.canrad.2021.03.002. Epub 2021 Apr 6.
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[Mandibular osteoradionecrosis (ORN) as a side effect of head and neck cancer treatment: Factors that induce it].[下颌骨放射性骨坏死作为头颈癌治疗的副作用:诱发因素]
Gac Med Mex. 2016 Nov-Dec;152(6):730-733.
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Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT).下颌骨放射性骨坏死:调强放射治疗(IMRT)后风险状况降至最低
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Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulated radiation therapy for head-and-neck cancer.头颈部癌症调强放射治疗中骨放射性坏死与牙科事件与剂量学参数的相关性。
Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e207-13. doi: 10.1016/j.ijrobp.2011.02.003. Epub 2011 May 11.
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The incidence and management of osteoradionecrosis of the jaws following head and neck radiotherapy.头颈部放疗后颌骨放射性骨坏死的发病率及处理
Br J Radiol. 1983 Nov;56(671):851-7. doi: 10.1259/0007-1285-56-671-851.
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Osteoradionecrosis of the mandible.下颌骨放射性骨坏死
Curr Opin Otolaryngol Head Neck Surg. 2005 Aug;13(4):217-21. doi: 10.1097/01.moo.0000170527.59017.ff.

引用本文的文献

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Cost-effectiveness of personalized policies for implementing organ-at-risk sparing adaptive radiation therapy in head and neck cancer.头颈部癌实施危及器官保留自适应放射治疗个性化策略的成本效益
Phys Imaging Radiat Oncol. 2025 May 6;34:100772. doi: 10.1016/j.phro.2025.100772. eCollection 2025 Apr.
2
Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.皮肤恶性肿瘤治疗后颅骨放射性骨坏死的管理:一项系统评价
Otolaryngol Head Neck Surg. 2025 Sep;173(3):552-565. doi: 10.1002/ohn.1290. Epub 2025 May 5.
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Radiographic classification of mandibular osteoradionecrosis: A blinded prospective multi-disciplinary interobserver diagnostic performance study.
下颌骨放射性骨坏死的影像学分类:一项盲法前瞻性多学科观察者间诊断性能研究。
Radiother Oncol. 2025 Jul;208:110917. doi: 10.1016/j.radonc.2025.110917. Epub 2025 May 2.
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Externally validated digital decision support tool for time-to-osteoradionecrosis risk-stratification using right-censored multi-institutional observational cohorts.使用右删失多机构观察性队列进行骨放射性坏死风险分层时间的外部验证数字决策支持工具。
Radiother Oncol. 2025 Jun;207:110890. doi: 10.1016/j.radonc.2025.110890. Epub 2025 Apr 11.
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Mechanism of skull base osteoradionecrosis explored through laboratory assessment with propensity score-matched analysis.通过倾向评分匹配分析的实验室评估探索颅底放射性骨坏死的机制。
Sci Rep. 2025 Mar 10;15(1):8323. doi: 10.1038/s41598-025-93020-6.
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Radiographic classification of mandibular osteoradionecrosis: A blinded prospective multi-disciplinary interobserver diagnostic performance study.下颌骨放射性骨坏死的影像学分类:一项盲法前瞻性多学科观察者间诊断性能研究。
medRxiv. 2025 Feb 14:2025.02.11.25322082. doi: 10.1101/2025.02.11.25322082.
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Endoscopic Endonasal Surgery of Skull Base Osteoradionecrosis with the Internal Carotid Artery Invaded: Clinical Characteristic and Surgical Strategy.内镜下经鼻手术治疗侵犯颈内动脉的颅底放射性骨坏死:临床特征与手术策略
Ther Clin Risk Manag. 2024 Dec 19;20:871-881. doi: 10.2147/TCRM.S479849. eCollection 2024.
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External validation of a multimodality deep-learning normal tissue complication probability model for mandibular osteoradionecrosis trained on 3D radiation distribution maps and clinical variables.基于3D放射分布图和临床变量训练的下颌骨放射性骨坏死多模态深度学习正常组织并发症概率模型的外部验证
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