Laboratoire National de Santé, Service de toxicologie analytique - chimie pharmaceutique, 1, Rue Louis Rech, 3555, Dudelange, Luxembourg.
Abrigado, 8, route de Thionville, 2610, Luxembourg, Luxembourg.
Harm Reduct J. 2021 Jan 7;18(1):8. doi: 10.1186/s12954-020-00457-1.
Reports from experienced heroin users about an alternative and appreciated but harmful so-called "Turkish" heroin preparation technic led to the chemical investigation of the compounds produced during this process and investigation of the presence of other psychoactive contaminants.
Comparison of diacetylmorphine, 6-monoacetylmorphine, morphine, paracetamol and caffeine concentrations were performed in the non-processed material, after processing according to the standard and to the alternative preparation methods using liquid chromatography coupled to quadrupole time of flight mass spectrometry followed by statistical evaluation of the results.
The two preparation methods had in common a diminution of diacetylmorphine as compared to the starting material but significantly more 6-monoacetylmorphine was produced using the "Turkish" preparation method as compared to the standard method.
The high amount of psychoactive 6-monoacetylmorphine may have an impact on the reported effects of heroin using the "Turkish" preparation procedure.
有经验的海洛因使用者报告了一种替代且备受推崇但有害的所谓“土耳其”海洛因制剂技术，这促使我们对该过程中产生的化合物进行了化学调查，并调查了是否存在其他具有致幻作用的污染物。
采用液相色谱-四极杆飞行时间质谱联用技术，对未经处理的材料、按照标准和替代制备方法处理后的材料进行了二乙酰吗啡、6-单乙酰吗啡、吗啡、对乙酰氨基酚和咖啡因浓度的比较，并对结果进行了统计评估。
与起始材料相比，两种制备方法都有二乙酰吗啡减少的共同点，但使用“土耳其”制备方法比标准方法产生的 6-单乙酰吗啡明显更多。
高含量的具有致幻作用的 6-单乙酰吗啡可能会对使用“土耳其”制备程序的海洛因报告效果产生影响。
