Service de Toxicologie Analytique - Chimie Pharmaceutique, Laboratoire National de Santé, 1, Rue Louis Rech, 3555, Dudelange, Luxembourg.
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Harm Reduct J. 2023 Aug 4;20(1):106. doi: 10.1186/s12954-023-00837-3.
Drug consumption rooms offer heroin and cocaine consumers a secure and hygienic environment including medical and social guidance. Despite the support and mentoring, only sparse information is available about how drug quality, drug prices and user expectations match at these locations. The present study reports analysis of these three parameters in two drug consumption rooms in Luxembourg.
Drug users were invited to participate in the project by handing in a few milligrams of the product they planned to consume for chemical analysis and filling out a short questionnaire about the price and their expectations. After consumption, they were asked to report the experienced effects. Drug quality was accessed using LC-Q-ToF and HPLC-UV, and a statistical analysis was carried out of the questionnaires that were correctly filled out.
A total of 513 drug samples have been analyzed. Most consumers were looking for the relaxing/calming effects of heroin and the stimulating effects of cocaine, but they generally overestimated heroin potency and underestimated cocaine potency. No strong correlation based on Spearman's ρ between drug user estimations, drug prices and drug quality was found.
To the best of our knowledge, this study is the first to combine drug analysis with heroin and cocaine user feedback about expectation, drug prices and drug effects. The analytical results were of great interest for users and the staff working at the drug consumption rooms. They may be a strong supplementary communication tool for health care workers when discussing effects and risks of highly toxic substance consumption.
毒品注射室为海洛因和可卡因使用者提供安全和卫生的环境，包括医疗和社会指导。尽管得到了支持和指导，但关于这些场所的毒品质量、毒品价格和用户期望如何匹配的信息却很少。本研究报告了在卢森堡的两个毒品注射室中对这三个参数的分析。
通过交回他们计划用于化学分析的几毫克产品，并填写有关价格和期望的简短问卷，邀请吸毒者参与该项目。消费后，他们被要求报告所经历的效果。使用 LC-Q-ToF 和 HPLC-UV 评估药物质量，并对正确填写的问卷进行统计分析。
共分析了 513 个药物样本。大多数消费者都在寻找海洛因的放松/镇静作用和可卡因的刺激作用，但他们普遍高估了海洛因的效力，低估了可卡因的效力。根据 Spearman's ρ，未发现药物使用者的估计、药物价格和药物质量之间存在强相关性。
据我们所知，这项研究首次将毒品分析与海洛因和可卡因使用者对期望、药物价格和药物效果的反馈结合起来。分析结果对使用者和毒品注射室的工作人员非常感兴趣。当讨论高毒性物质消费的效果和风险时，它们可能是医疗保健工作者的一个强有力的补充沟通工具。
