Weigel M M, Weigel R M
Department of Obstetrics and Gynecology, School of Medicine, Oregon Health Sciences University, Portland 97201.
Am J Epidemiol. 1988 Mar;127(3):562-70. doi: 10.1093/oxfordjournals.aje.a114831.
The role of maternal risk factors in the development of nausea and vomiting in pregnancy was studied in a historical cohort of 825 women who gave birth at the University of California (Los Angeles) Medical Center during a one-year period (April 1983-March 1984). The roles of demographic factors, reproductive history, and consumption of alcohol and tobacco in affecting the risk of developing nausea and vomiting were studied using both bivariate and multivariate statistical methods. Interpretations of the statistical analyses identify three risk factor associations correlated with decreased risk of nausea and vomiting and one factor associated with increased risk. The most apparent pattern was that women who were ethnically white, of white collar or professional occupation, and who consumed alcohol prior to conception, were at decreased risk for nausea and vomiting. The second pattern of decreased risk consisted of women over 35 years old with a history of infertility for one or more years prior to the current conception. The third low-risk pattern consisted of women without a history of nausea during prior pregnancies. The only factor associated with an increased risk was housewife occupational status. The results of this study are consistent with an endocrinologic model for the etiology of pregnancy-induced nausea and vomiting.
在一项历史性队列研究中，对825名在一年期间（1983年4月至1984年3月）于加利福尼亚大学（洛杉矶）医学中心分娩的女性进行了研究，以探讨孕产妇风险因素在妊娠期恶心和呕吐发生中的作用。使用双变量和多变量统计方法研究了人口统计学因素、生殖史以及酒精和烟草消费对发生恶心和呕吐风险的影响。统计分析结果表明，有三个风险因素与恶心和呕吐风险降低相关，一个因素与风险增加相关。最明显的模式是，种族为白人、从事白领或专业职业且在受孕前饮酒的女性，恶心和呕吐风险降低。第二个风险降低模式包括在本次受孕前有一年或多年不孕史的35岁以上女性。第三个低风险模式包括既往妊娠期间无恶心史的女性。唯一与风险增加相关的因素是家庭主妇职业状况。本研究结果与妊娠剧吐病因的内分泌学模型一致。
