Lacasse Anaïs, Rey Evelyne, Ferreira Ema, Morin Caroline, Bérard Anick
Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada.
BMC Pregnancy Childbirth. 2009 Jul 2;9:26. doi: 10.1186/1471-2393-9-26.
Studies that contributed to the epidemiology of nausea and vomiting of pregnancy have reported conflicting findings, and often failed to account for all possible co-variables necessary to evaluate the multidimensional associations. The objectives of this study were to: 1) Estimate the prevalence and the severity of nausea and vomiting of pregnancy during the 1st and the 2nd trimester of pregnancy, and 2) Identify determinants of presence and severity of nausea and vomiting of pregnancy during the 1st and 2nd trimesters separately, with a special emphasis on the impact of race/ethnicity.
A prospective study including pregnant women attending the Centre Hospitalier Universitaire (CHU) Sainte-Justine or René-Laennec clinics for their prenatal care was conducted from 2004 to 2006. Women were eligible if they were > or = 18 years of age, and </= 16 weeks of gestation. Women were asked to fill out a 1st trimester self-administered questionnaire and were interviewed over the telephone during their 2nd trimester of pregnancy. Presence of nausea and vomiting of pregnancy was based on the reporting of pregnant women (yes/no); severity of symptoms was measured by the validated modified-PUQE index.
Of the 367 women included in the study, 81.2% were Caucasians, 10.1% Blacks, 4.6% Hispanics, and 4.1% Asians. Multivariate analyses showed that race/ethnicity was significantly associated with a decreased likelihood of reporting nausea and vomiting of pregnancy (Asians vs. Caucasians OR: 0.13; 95%CI 0.02-0.73; and Blacks vs. Caucasians OR: 0.29; 95%CI 0.09-0.99).
Our study showed that race/ethnicity was associated with the reporting of nausea and vomiting of pregnancy in the 1st trimester of pregnancy.
关于妊娠恶心和呕吐流行病学的研究报告结果相互矛盾，且往往未能考虑评估多维关联所需的所有可能协变量。本研究的目的是：1）估计妊娠第1和第2孕期妊娠恶心和呕吐的患病率及严重程度，2）分别确定妊娠第1和第2孕期妊娠恶心和呕吐存在及严重程度的决定因素，特别强调种族/民族的影响。
2004年至2006年进行了一项前瞻性研究，纳入在圣朱斯汀大学医院（CHU）或勒内·拉埃内克诊所接受产前护理的孕妇。年龄≥18岁且妊娠≤16周的女性符合条件。要求女性填写一份孕早期自我管理问卷，并在妊娠第2孕期接受电话访谈。妊娠恶心和呕吐的存在基于孕妇的报告（是/否）；症状严重程度通过经过验证的改良PUQE指数进行测量。
纳入研究的367名女性中，81.2%为白种人，10.1%为黑人，4.6%为西班牙裔，4.1%为亚洲人。多变量分析显示，种族/民族与报告妊娠恶心和呕吐的可能性降低显著相关（亚洲人与白种人相比，比值比：0.13；95%可信区间0.02 - 0.73；黑人与白种人相比，比值比：0.29；95%可信区间0.09 - 0.99）。
我们的研究表明，种族/民族与妊娠第1孕期妊娠恶心和呕吐的报告相关。
