Lempert K D, Rogers J S, Albrink M J
Division of Nephrology, Medical College of Ohio, Toledo 43699.
Am J Kidney Dis. 1988 Feb;11(2):170-5. doi: 10.1016/s0272-6386(88)80207-5.
The effects of a daily fish oil supplement rich in eicosapentaenoic acid were studied in 11 stable continuous ambulatory peritoneal dialysis (CAPD) patients. Serum lipids, platelet aggregation studies, and template bleeding times were determined before and after 4 weeks of fish oil treatment. The lipid studies were repeated approximately 20 weeks after stopping fish oil supplement. At the end of the treatment period, serum triglycerides (mean +/- SEM) decreased from 297 +/- 42 to 211 +/- 29 mg/dL (P less than .01), high density lipoprotein (HDL) cholesterol fell from 45 +/- 3 to 41 +/- 3 mg/dL (P less than .05), and low density lipoprotein (LDL) cholesterol increased from 172 +/- 16 to 208 +/- 19 mg/dL (P less than .05). After discontinuing the fish oil supplement, the triglycerides increased to 278 +/- 39 mg/dL, which was no different than the value before fish oil treatment. No significant changes occurred in template bleeding time (TBT), platelet count, hematocrit, or platelet aggregation response. Clinically important uremic bleeding was not apparent. We conclude that in CAPD patients a fish oil supplement favorably effects hypertriglyceridemia and can be ingested without promoting uremic bleeding. The likely beneficial impact on atherogenesis resulting from the lowering of the triglycerides may, however, be counteracted by concomitant changes in HDL- and LDL-cholesterol.
对11名稳定的持续性非卧床腹膜透析（CAPD）患者研究了每日补充富含二十碳五烯酸的鱼油的效果。在鱼油治疗4周前后测定血清脂质、血小板聚集研究和模板出血时间。在停止补充鱼油约20周后重复进行脂质研究。在治疗期结束时，血清甘油三酯（均值±标准误）从297±42降至211±29mg/dL（P＜0.01），高密度脂蛋白（HDL）胆固醇从45±3降至41±3mg/dL（P＜0.05），低密度脂蛋白（LDL）胆固醇从172±16增至208±19mg/dL（P＜0.05）。停止补充鱼油后，甘油三酯增至278±39mg/dL，与鱼油治疗前的值无差异。模板出血时间（TBT）、血小板计数、血细胞比容或血小板聚集反应无显著变化。临床上重要的尿毒症出血不明显。我们得出结论，在CAPD患者中，补充鱼油对高甘油三酯血症有有利影响，并且可以在不促进尿毒症出血的情况下摄入。然而，甘油三酯降低对动脉粥样硬化形成可能的有益影响可能会被HDL胆固醇和LDL胆固醇的伴随变化所抵消。
