Le Heuzey J Y, Guize L
Pierre and Marie Curie University (Broussais Hospital), Paris, France.
Am J Med. 1988 Jan 29;84(1B):65-8.
The cardiac prognosis of hypertensive patients has been able to be precisely determined over the last 20 years as a result of large-scale epidemiologic surveys. The incidence of ischemic heart disease and the importance of left ventricular hypertrophy have been clearly defined in the literature. In contrast, the incidence of sudden death and ventricular arrhythmias has been poorly taken into account, although hypertension increases the risk of sudden death to the same degree as coronary artery disease. The relative risk increases progressively as a function of the quintiles of distribution of blood pressure, reaching a value of 3.2 for the highest quintile. There is also a significant correlation between hypertension and ventricular arrhythmias. Hypertensive subjects with other cardiovascular risk factors such as hypercholesterolemia or smoking and with ventricular extrasystoles, reflecting the presence of silent ischemia, can be considered to be at high risk of cardiac death.
在过去20年里，通过大规模流行病学调查，高血压患者的心脏预后已能够被精确判定。缺血性心脏病的发病率以及左心室肥厚的重要性在文献中已有明确界定。相比之下，尽管高血压使猝死风险增加的程度与冠状动脉疾病相同，但猝死和室性心律失常的发病率却未得到充分考量。相对风险随血压分布五分位数的增加而逐渐上升，最高五分位数时达到3.2。高血压与室性心律失常之间也存在显著相关性。伴有其他心血管危险因素（如高胆固醇血症或吸烟）以及室性早搏（反映存在无症状性心肌缺血）的高血压患者，可被视为心脏死亡的高危人群。
