PALB2缺失预示急性髓系白血病预后不良，并提示针对DNA修复途径的新型治疗策略。 - Suppr

Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway.

作者信息

Padella Antonella, Fontana Maria Chiara, Marconi Giovanni, Fonzi Eugenio, Petracci Elisabetta, Ferrari Anna, Baldazzi Carmen, Papayannidis Cristina, Ghelli Luserna Di Rorá Andrea, Testoni Nicoletta, Castellani Gastone, Haferlach Torsten, Martinelli Giovanni, Simonetti Giorgia

机构信息

Istituto Scientifico Romagnolo per lo Studio e Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

Azienda Ospedaliero-Universitaria di Bologna, via Albertoni 15, Bologna, Italia, Istituto di Ematologia "Seràgnoli", Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, Bologna, Italia.

出版信息

Blood Cancer J. 2021 Jan 7;11(1):7. doi: 10.1038/s41408-020-00396-x.

DOI:10.1038/s41408-020-00396-x

PMID:33414401

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7791026/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4f/7791026/b9f9a83870c7/41408_2020_396_Fig1_HTML.jpg

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Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway.

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