Barkley Jacob E, Vucetic Henry, Leone David, Mehta Bina, Rebold Michael, Kobak Mallory, Carnes Andrew, Farnell Gregory
Department of Exercise Science, Kent State University, Kent, OH, USA.
The Spine and Pain Institute, Kent, OH, USA.
Int J Exerc Sci. 2020 Dec 1;13(3):1583-1594. doi: 10.70252/EVIW5224. eCollection 2020.
The purpose of this study was to assess changes in pain and physical activity after replacing a traditional spinal cord stimulation (SCS) implantable pulse generator with a next generation SCS in patients for whom traditional SCS was no longer providing adequate relief of low back and/or leg pain. Subjects ( = 19) who reported that they were no longer receiving adequate relief from traditional SCS were implanted with a next generation SCS. Eighteen additional patients who were receiving relief from traditional SCS were also followed as a control. Both groups (next generation, traditional) were assessed for low-back and limb pain (visual analog scale) and daily physical activity (wearable accelerometer) at baseline and three, six, nine and 12 months following the SCS implant. Relative to baseline, next generation SCS subjects exhibited reductions ( ≤ 0.05 for all) in low-back pain (average reduction of 22%) at every time point, in leg pain (average reduction of 23%) at every time point except six months and increased physical activity (average increase of 57%) at three, six and nine months. As expected, there were no changes in pain or physical activity in the traditional SCS subjects ( ≥ 0.1). In conclusion, pain decreased, and physical activity increased in patients receiving a next generation SCS. Physical activity may serve as an objectively measured marker of pain.
本研究的目的是评估在传统脊髓刺激（SCS）植入式脉冲发生器不再能充分缓解腰和/或腿痛的患者中，用新一代SCS替换传统SCS后疼痛和身体活动的变化。报告称传统SCS不再能充分缓解疼痛的受试者（n = 19）植入了新一代SCS。另外18名从传统SCS中获得缓解的患者也作为对照进行随访。两组（新一代、传统组）在SCS植入后的基线、3个月、6个月、9个月和12个月时，均接受了腰和肢体疼痛（视觉模拟量表）及日常身体活动（可穿戴式加速度计）的评估。相对于基线，新一代SCS受试者在每个时间点的腰背痛均有减轻（所有时间点P≤0.05，平均减轻22%），除6个月外的每个时间点腿痛均有减轻（平均减轻23%），且在3个月、6个月和9个月时身体活动增加（平均增加57%）。正如预期的那样，传统SCS受试者的疼痛或身体活动没有变化（P≥0.1）。总之，接受新一代SCS的患者疼痛减轻，身体活动增加。身体活动可能是疼痛的一个客观测量指标。
