Khan Habib, Hussain Azhar, Chaubey Sanjay, Sameh Mohamed, Salter Inga, Deshpande Ranjit, Baghai Max, Wendler Olaf
Department of Cardiothoracic Surgery, King's College Hospital, London, UK.
J Card Surg. 2021 Mar;36(3):952-958. doi: 10.1111/jocs.15292. Epub 2021 Jan 8.
Acute aortic dissection type-A (AADA) is a life threatening condition which requires emergency surgery. Surgery is usually performed by cardiac surgeons with various levels of aortic surgical experience. We compared the short-term perioperative outcome and long-term survival of patients operated by specialist aortic surgeons (SASs)and those who were operated by surgeons without specialist expertise.
A single center retrospective review of 232 patients who underwent acute surgery for AADA was conducted between 2005 and 2020. The cohort was divided into those operated on by SASs (Group A, n = 186) and those operated on by nonaortic surgeons (Group B, n = 46). Statistical comparison was done using regression modelling and groups were propensity matched. Kaplan-Meier comparison was undertaken using STATA14.
Of 232 patients, 186 were operated on by an aortic specialist and 46 were operated by a nonaortic specialist. Overall 30-day mortality was 10% in Group A compared to 26.0% in Group B (unadjusted: p = .01, multivariate: p = .02, and propensity matched p = .05). Long-term mortality at 14 years was 26% in Group A compared to 52.0% in Group B (unadjusted: p = .001, multivariate: p = .001, and propensity matched: p = .01). Aortic surgeons performed a significantly higher number of aortic root procedures (43.0% vs. 17.3%, p = .001). The cross-clamp time and bypass time was significantly shorter in Group A patients (89 vs. 105 min, p < .01 and 153 vs. 185, p = < .001). Postoperative requirement for renal filtration was (19% vs. 37%, unadjusted p = .01, multivariate p = .03 and propensity matched p = .04). Although postoperative bleeding was less in Group A (4.0% vs. 11.0%, unadjusted p = .05) after propensity matching it was not statistically significant.
In patients with AADA, surgery performed by aortic specialist's results in improved outcomes. Aortic specialists replaced more of dissected aorta, resulting in an increased number of complex procedures, which may explain improved long-term survival after AADA in this cohort. This study adds further support in establishing a specialist aortic surgical service in cardiac centers.
急性A型主动脉夹层(AADA)是一种危及生命的疾病,需要紧急手术。手术通常由具有不同主动脉手术经验水平的心脏外科医生进行。我们比较了由主动脉专科医生(SASs)手术的患者与由无专科专业知识的外科医生手术的患者的短期围手术期结局和长期生存率。
对2005年至2020年间接受AADA急诊手术的232例患者进行单中心回顾性研究。该队列分为由SASs手术的患者(A组,n = 186)和由非主动脉外科医生手术的患者(B组,n = 46)。使用回归模型进行统计比较,并对各组进行倾向匹配。使用STATA14进行Kaplan-Meier比较。
在232例患者中,186例由主动脉专科医生手术,46例由非主动脉专科医生手术。A组的总体30天死亡率为10%,而B组为26.0%(未调整:p = .01,多变量:p = .02,倾向匹配p = .05)。A组14年的长期死亡率为26%,而B组为52.0%(未调整:p = .001,多变量:p = .001,倾向匹配:p = .01)。主动脉外科医生进行的主动脉根部手术数量明显更多(43.0%对17.3%,p = .001)。A组患者的主动脉阻断时间和体外循环时间明显更短(89对105分钟,p < .01;153对185,p = < .001)。术后肾脏滤过的需求为(19%对37%,未调整p = .01,多变量p = .03,倾向匹配p = .04)。虽然倾向匹配后A组术后出血较少(4.0%对11.0%,未调整p = .05),但差异无统计学意义。
在AADA患者中,由主动脉专科医生进行的手术可改善结局。主动脉专科医生替换了更多的夹层主动脉,导致复杂手术数量增加,这可能解释了该队列中AADA患者长期生存率的提高。本研究为在心脏中心建立专科主动脉外科服务提供了进一步支持。