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经上半部分胸骨正中切口与传统胸骨正中切口行升主动脉手术治疗复杂主动脉夹层的对比研究

Surgery of ascending aorta with complex procedures for aortic dissection through upper mini-sternotomy versus conventional sternotomy.

作者信息

Wu Yang, Jiang Wei, Li Dong, Chen Lei, Ye Weihua, Ren Chonglei, Xiao Cangsong

机构信息

Department of Cardiovascular Surgery, PLA General Hospital, 28 Fuxing Road, Beijing, China.

出版信息

J Cardiothorac Surg. 2020 Apr 7;15(1):57. doi: 10.1186/s13019-020-01095-1.

Abstract

BACKGROUND

Use of minimally invasive approaches for isolated aortic valve or ascending aorta surgery is increasing. However, total arch replacement or aortic root repair through a minimally invasive incision is rare. This study was performed to report our initial experience with surgery of the ascending aorta with complex procedures through an upper mini-sternotomy approach.

METHODS

We retrospectively analyzed 80 patients who underwent ascending aorta replacement combined with complex procedures including hemi-arch, total arch, and aortic root surgeries from September 2010 to May 2018. Using standard propensity score-matching analysis, 36 patients were matched and divided into 2 groups: the upper mini-sternotomy group (n = 18) and the median sternotomy group (n = 18). The preoperative assessment revealed no statistically significant differences between the two groups.

RESULTS

Hospital mortality occurred in one patient (2.8%). The mini-sternotomy group showed a longer cross-clamping time (160 ± 38 vs. 135 ± 36 min, p = 0.048) due to higher rate of valve-sparing aortic root replacement and total arch repair. The cardiopulmonary bypass time in mini-sternotomy group was shorter than that of full sternotomy group (209 ± 47 min vs 218 ± 62 min, p = 0.595) but fell short of significance. There was no significant difference in lower body hypothermia circulatory arrest time between the two groups (40 ± 10 min vs 48 ± 20 min, p = 0.139). The upper mini-sternotomy group displayed a shorter ventilation time (22 vs. 45 h, p = 0.014), intensive care unit stay (4.6 ± 2.7 vs. 7.9 ± 3.7 days, p = 0.005), and hospital stay (8.2 ± 3.8 vs. 21.4 ± 11.9 days, p = 0.001). The upper mini-sternotomy group showed a lower postoperative red blood cell transfusion volume (4.6 ± 3.3 vs. 6.7 ± 5.7 units, p = 0.042) and postoperative drainage volume (764 ± 549 vs. 1255 ± 745 ml, p = 0.034). The rates of dialysis for newly occurring renal failure, neurological complications, and re-exploration were similar between the two groups (p = 1.000).

CONCLUSION

The upper mini-sternotomy approach is safe and beneficial in ascending aorta surgery with complex procedures for aortic dissection, including total arch replacement and aortic root repair.

摘要

背景

孤立性主动脉瓣或升主动脉手术采用微创方法的情况日益增多。然而,通过微创切口进行全弓置换或主动脉根部修复却较为罕见。本研究旨在报告我们通过上半部分胸骨正中切口入路进行升主动脉复杂手术的初步经验。

方法

我们回顾性分析了2010年9月至2018年5月期间接受升主动脉置换联合复杂手术(包括半弓、全弓和主动脉根部手术)的80例患者。采用标准倾向评分匹配分析,36例患者进行匹配并分为两组:上半部分胸骨正中切口组(n = 18)和胸骨正中切口组(n = 18)。术前评估显示两组之间无统计学显著差异。

结果

1例患者(2.8%)发生医院死亡。由于保留瓣膜的主动脉根部置换和全弓修复率较高,上半部分胸骨正中切口组的主动脉阻断时间更长(160±38分钟对135±36分钟,p = 0.048)。上半部分胸骨正中切口组的体外循环时间短于胸骨正中切口组(209±47分钟对218±62分钟,p = 0.595),但未达到显著差异。两组之间下半身低温循环停滞时间无显著差异(40±10分钟对48±20分钟,p = 0.139)。上半部分胸骨正中切口组显示通气时间更短(2天对4.5天(此处原文有误,根据语境推测后一组应为45小时,翻译为4.5天便于理解),p = 0.014)、重症监护病房住院时间更短(4.6±2.7天对7.9±3.7天,p = 0.005)以及住院时间更短(8.2±3.8天对21.4±11.9天,p = 0.001)。上半部分胸骨正中切口组术后红细胞输注量更低(4.6±3.3单位对6.7±5.7单位,p = 0.042)以及术后引流量更低(764±549毫升对1255±745毫升,p = 0.034)。两组新发生肾衰竭的透析率、神经系统并发症和再次手术率相似(p = 1.000)。

结论

对于包括全弓置换和主动脉根部修复在内的主动脉夹层复杂升主动脉手术,上半部分胸骨正中切口入路是安全且有益的。

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