Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou 515041, P.R. China.
Department of Head and Neck Surgery, The Cancer Hospital of Shantou University Medical College, Shantou 515041, P.R. China.
Oncol Rep. 2021 Feb;45(2):427-438. doi: 10.3892/or.2020.7892. Epub 2020 Dec 9.
The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling effector, has been extensively investigated in many malignant cancers. Over the last few decades, IGFBP2, a key member of the IGFBP family, has been identified as an important oncogene in multiple human cancers. In addition, a growing number of studies have shown that IGFBP2 is greatly elevated in serum or tissue in patients with malignant tumors and plays an essential role in several key oncogenic processes, such as tumor cellular proliferation, migration, invasion, angiogenesis, epithelial‑to‑mesenchymal transition, and immunoregulation, which are involved in a variety of signal pathways, usually via an IGF‑independent means. Moreover, growing evidence indicates that aberrant overexpression of IGFBP2 may serve as a useful biomarker for the diagnosis and prognosis of patients, as well as act as a potential therapeutic target for the management of clinical treatment in patients with malignant disease. In the present review, we summarize the current points of view that IGFBP2 performs a role in the initiation and progression of various types of cancer by interacting with several key molecules involved in cancer signaling pathways. We also discuss its potential clinical application value as a diagnostic/prognostic biomarker for patients with malignant tumors.
IGFBP2 的多功能性，作为癌细胞中的分泌蛋白或细胞质信号效应物，在许多恶性癌症中得到了广泛研究。在过去的几十年中，IGFBP2 作为 IGFBP 家族的一个关键成员，已被确定为多种人类癌症中的重要癌基因。此外，越来越多的研究表明，IGFBP2 在恶性肿瘤患者的血清或组织中大量升高，并在几种关键致癌过程中发挥重要作用，如肿瘤细胞增殖、迁移、侵袭、血管生成、上皮间质转化和免疫调节，这些过程涉及多种信号通路，通常通过 IGF 非依赖性途径。此外，越来越多的证据表明，IGFBP2 的异常过表达可能作为患者诊断和预后的有用生物标志物，并作为恶性疾病患者临床治疗管理的潜在治疗靶点。在本综述中，我们总结了 IGFBP2 通过与癌症信号通路中涉及的几个关键分子相互作用，在各种类型癌症的发生和进展中发挥作用的观点。我们还讨论了它作为恶性肿瘤患者诊断/预后生物标志物的潜在临床应用价值。
