Miao Wenjun, Ni Chuanfa, Xiao Pan, Jia Rulong, Zhang Wei, Hu Jinbo
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
College of Basic Medicine, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, China.
Org Lett. 2021 Feb 5;23(3):711-715. doi: 10.1021/acs.orglett.0c03939. Epub 2021 Jan 8.
A novel nickel-catalyzed reductive cross-coupling between aryl iodides and difluoromethyl 2-pyridyl sulfone (2-PySOCFH) enables C(sp)-C(sp) bond formation through selective C(sp)-S bond cleavage, which demonstrates the new reactivity of 2-PySOCFH reagent. This method employs readily available nickel catalyst and sulfones as cross-electrophile coupling partners, providing facile access to biaryls under mild reaction conditions without pregeneration of arylmetal reagents.
一种新型的镍催化芳基碘化物与二氟甲基2-吡啶基砜（2-PySOCFH）之间的还原交叉偶联反应，能够通过选择性的C(sp)-S键断裂实现C(sp)-C(sp)键的形成，这展示了2-PySOCFH试剂的新反应活性。该方法使用易于获得的镍催化剂和砜作为交叉亲电偶联伙伴，在温和的反应条件下无需预先生成芳基金属试剂即可轻松制备联芳基化合物。
