原始蛋白质尾巴
Primordial Protein Tails.
作者信息
Brandman Onn, Frost Adam
机构信息
Department of Biochemistry, Stanford University, Palo Alto, CA 94305, USA.
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
出版信息
Mol Cell. 2021 Jan 7;81(1):6-7. doi: 10.1016/j.molcel.2020.12.032.
Abstract
C-terminal tailing is an ancient and conserved form of peptide synthesis that protects cells from incomplete and potentially toxic translation products. Filbeck et al. (2020) and Crowe-McAuliffe et al. (2020) use structural, genetic, and biochemical approaches to elucidate the mechanisms driving C-terminal tailing.
摘要
C末端加尾是一种古老且保守的肽合成形式，可保护细胞免受不完整且可能有毒的翻译产物的影响。菲尔贝克等人（2020年）和克罗-麦考利夫等人（2020年）使用结构、遗传和生化方法来阐明驱动C末端加尾的机制。
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本文引用的文献
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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.RqcH 和 RqcP 通过细菌核糖体相关质量控制的结构基础。
Mol Cell. 2021 Jan 7;81(1):115-126.e7. doi: 10.1016/j.molcel.2020.11.002. Epub 2020 Nov 30.
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NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.NEMF 突变会损害与核糖体相关的质量控制，与神经肌肉疾病有关。
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Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control.通过核糖体相关质量控制检测和降解停滞的新生链。
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MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure.MINERVA 机制上把线粒体功能障碍与蛋白质稳态失效联系起来。
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Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control.丙氨酸尾巴信号在细菌核糖体相关质量控制中的蛋白水解作用。
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