种间嵌合体中的生长竞争：囊胚互补的新范例。
Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation.
机构信息
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Cell Stem Cell. 2021 Jan 7;28(1):3-5. doi: 10.1016/j.stem.2020.12.011.
Blastocyst complementation represents a powerful technique for interspecies organogenesis but is limited by low chimerism due to developmental incompatibilities. In this issue of Cell Stem Cell,Nishimura et al. (2021) circumvent early developmental barriers by disabling Igf1r in host embryos, conferring donor cells with a growth advantage from mid-gestation onward.
囊胚互补代表了一种强大的种间器官发生技术，但由于发育不相容性，嵌合体率低限制了其应用。在本期《Cell Stem Cell》中，Nishimura 等人（2021）通过在宿主胚胎中失活 Igf1r 来规避早期发育障碍，从而使供体细胞从中期妊娠开始获得生长优势。
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